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Piclidenoson

Name: Piclidenoson
Brand: TargetMol
SKU: T7188
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7188Cas No. 152918-18-8

Alias IB-MECA, CF-101

Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.

Piclidenoson

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Purity: 99.83%

Catalog No. T7188Alias IB-MECA, CF-101Cas No. 152918-18-8

Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$91	In Stock	In Stock
25 mg	$193	In Stock	In Stock
50 mg	$313	In Stock	In Stock
100 mg	$488	In Stock	In Stock
200 mg	$698	-	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.83%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.
In vitro	Piclidenoson inhibited the proliferation of HaCat cells through deregulation of the NF-κB signaling pathway, leading to a decrease in interleukin-17 and interleukin-23 expression levels[1].
Cell Research	[3H]-Thymidine incorporation assay was used to evaluate cell growth.?HaCat cells (2500 cells/well) were incubated with piclidenoson 10?nM and MRS 1523 (50?nM) in 96-well plate for 48 hours.?For the last 24 hours of incubation, each well was pulsed with 1?mCi [3H]-thymidine.?Cells were harvested, and the [3H]-thymidine uptake was determined in an LKB liquid scintillation counter (LKB, Piscataway, NJ, USA).?These experiments were repeated at least 4 times[1].
Synonyms	IB-MECA, CF-101

Chemical Properties

Molecular Weight	510.29
Formula	C₁₈H₁₉IN₆O₄
Cas No.	152918-18-8
Smiles	CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)ncnc12
Relative Density.	1.98g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (117.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9597 mL	9.7983 mL	19.5967 mL	97.9835 mL
5 mM	0.3919 mL	1.9597 mL	3.9193 mL	19.5967 mL
10 mM	0.1960 mL	0.9798 mL	1.9597 mL	9.7983 mL
20 mM	0.0980 mL	0.4899 mL	0.9798 mL	4.8992 mL
50 mM	0.0392 mL	0.1960 mL	0.3919 mL	1.9597 mL
100 mM	0.0196 mL	0.0980 mL	0.1960 mL	0.9798 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc