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Piclidenoson

Name: Piclidenoson
Brand: TargetMol
SKU: T7188
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7188Cas No. 152918-18-8

Alias IB-MECA, CF-101

Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.

Piclidenoson

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Purity: 99.83%

Catalog No. T7188Alias IB-MECA, CF-101Cas No. 152918-18-8

Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$91	In Stock	In Stock
25 mg	$193	In Stock	In Stock
50 mg	$313	In Stock	In Stock
100 mg	$488	In Stock	In Stock
200 mg	$698	-	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.83%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.
In vitro	Piclidenoson inhibited the proliferation of HaCat cells through deregulation of the NF-κB signaling pathway, leading to a decrease in interleukin-17 and interleukin-23 expression levels[1].
Cell Research	[3H]-Thymidine incorporation assay was used to evaluate cell growth.?HaCat cells (2500 cells/well) were incubated with piclidenoson 10?nM and MRS 1523 (50?nM) in 96-well plate for 48 hours.?For the last 24 hours of incubation, each well was pulsed with 1?mCi [3H]-thymidine.?Cells were harvested, and the [3H]-thymidine uptake was determined in an LKB liquid scintillation counter (LKB, Piscataway, NJ, USA).?These experiments were repeated at least 4 times[1].
Synonyms	IB-MECA, CF-101

Chemical Properties

Molecular Weight	510.29
Formula	C₁₈H₁₉IN₆O₄
Cas No.	152918-18-8
Smiles	CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)ncnc12
Relative Density.	1.98g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (117.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9597 mL	9.7983 mL	19.5967 mL	97.9835 mL
5 mM	0.3919 mL	1.9597 mL	3.9193 mL	19.5967 mL
10 mM	0.1960 mL	0.9798 mL	1.9597 mL	9.7983 mL
20 mM	0.0980 mL	0.4899 mL	0.9798 mL	4.8992 mL
50 mM	0.0392 mL	0.1960 mL	0.3919 mL	1.9597 mL
100 mM	0.0196 mL	0.0980 mL	0.1960 mL	0.9798 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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