Shopping Cart

Remove All
Your shopping cart is currently empty

Piclidenoson

Name: Piclidenoson
Brand: TargetMol
SKU: T7188
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7188Cas No. 152918-18-8

Alias IB-MECA, CF-101

Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.

Piclidenoson

🥰Excellent

Purity: 99.83%

Catalog No. T7188Alias IB-MECA, CF-101Cas No. 152918-18-8

Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$56	In Stock
10 mg	$91	In Stock
25 mg	$193	In Stock
50 mg	$313	In Stock
100 mg	$488	In Stock
200 mg	$698	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.83%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.
In vitro	Piclidenoson inhibited the proliferation of HaCat cells through deregulation of the NF-κB signaling pathway, leading to a decrease in interleukin-17 and interleukin-23 expression levels[1].
Cell Research	[3H]-Thymidine incorporation assay was used to evaluate cell growth.?HaCat cells (2500 cells/well) were incubated with piclidenoson 10?nM and MRS 1523 (50?nM) in 96-well plate for 48 hours.?For the last 24 hours of incubation, each well was pulsed with 1?mCi [3H]-thymidine.?Cells were harvested, and the [3H]-thymidine uptake was determined in an LKB liquid scintillation counter (LKB, Piscataway, NJ, USA).?These experiments were repeated at least 4 times[1].
Synonyms	IB-MECA, CF-101

Chemical Properties

Molecular Weight	510.29
Formula	C₁₈H₁₉IN₆O₄
Cas No.	152918-18-8
Smiles	CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)ncnc12
Relative Density.	1.98g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (117.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9597 mL	9.7983 mL	19.5967 mL	97.9835 mL
5 mM	0.3919 mL	1.9597 mL	3.9193 mL	19.5967 mL
10 mM	0.1960 mL	0.9798 mL	1.9597 mL	9.7983 mL
20 mM	0.0980 mL	0.4899 mL	0.9798 mL	4.8992 mL
50 mM	0.0392 mL	0.1960 mL	0.3919 mL	1.9597 mL
100 mM	0.0196 mL	0.0980 mL	0.1960 mL	0.9798 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc