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Dehydrocorydaline chloride

Name: Dehydrocorydaline chloride
Brand: TargetMol
SKU: T10990
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10990Cas No. 10605-03-5

Alias 13-Methylpalmatine chloride

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid exhibiting anti-inflammatory and anti-cancer activities and can enhance the activation of p38 MAPK.

Dehydrocorydaline chloride

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Purity: 99.53%

Catalog No. T10990Alias 13-Methylpalmatine chlorideCas No. 10605-03-5

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid exhibiting anti-inflammatory and anti-cancer activities and can enhance the activation of p38 MAPK.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$278	In Stock	In Stock
50 mg	$417	-	In Stock
100 mg	$593	-	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.53%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid exhibiting anti-inflammatory and anti-cancer activities and can enhance the activation of p38 MAPK.
In vitro	Treatment of C2C12 myoblasts with 500 nM dehydrocorydrine increased the expression of muscle-specific proteins (including MyoD, myogenin, and myosin heavy chain), and enhanced p38 MAPK activation and the interaction between MyoD and E protein. Additionally, dehydrohydroxyproline restored defects in differentiation-induced p38 MAPK activation and differentiation of myoblasts caused by Cdo. Dehydrohydroxyproline significantly inhibited MCF-7 cell proliferation in a dose-dependent manner, reversible by the caspase-8 inhibitor Z-IETD-FMK. It also increased DNA fragmentation without affecting ΔΨm, elevated Bax protein levels, decreased Bcl-2 protein levels, and induced caspase-7 and -8 activation and PARP cleavage, without affecting caspase-9. These findings suggest that dehydrohydroxyproline inhibits MCF-7 cell proliferation by inducing apoptosis through Bax/Bcl-2 regulation, caspase activation, and PARP cleavage.
In vivo	Dehydrocobaltate (3.6, 6 or 10 mg/kg, intraperitoneal injection) showed a dose-dependent anti-nociceptive effect in the acetic acid-induced writhing test and significantly reduced formalin-induced mice Pain reaction. In the formalin test, dehydrocorydrine can reduce the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. It was confirmed that dehydroyanhusine has an analgesic effect on mice.
Synonyms	13-Methylpalmatine chloride

Chemical Properties

Molecular Weight	401.88
Formula	C₂₂H₂₄ClNO₄
Cas No.	10605-03-5
Smiles	[Cl-].COc1ccc2c(C)c3-c4cc(OC)c(OC)cc4CC[n+]3cc2c1OC
Relative Density.	1.23g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 24 mg/mL (59.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4883 mL	12.4415 mL	24.8830 mL	124.4152 mL
5 mM	0.4977 mL	2.4883 mL	4.9766 mL	24.8830 mL
10 mM	0.2488 mL	1.2442 mL	2.4883 mL	12.4415 mL
20 mM	0.1244 mL	0.6221 mL	1.2442 mL	6.2208 mL
50 mM	0.0498 mL	0.2488 mL	0.4977 mL	2.4883 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc