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Trimethadione
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Catalog No. T0283Cas No. 127-48-0
Alias 3,5,5,-Trimethyloxazolidine-2,4-dione
Trimethadione (3,5,5-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity.
Trimethadione
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Purity: 99.94%
Catalog No. T0283Alias 3,5,5,-Trimethyloxazolidine-2,4-dioneCas No. 127-48-0
Trimethadione (3,5,5-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $47 | In Stock | In Stock | |
| 200 mg | $68 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.94%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Trimethadione AI Summary
Trimethadione exhibits a range of bioactivities, including significant anticonvulsant effects, neurotoxicity, and moderate hepatotoxicity. It inhibits [3H]-BTX-B binding to sodium channels in rat brain synapto-neurosomes with an IC50 value greater than 1,000,000 nM, and has shown anticonvulsant activity in mice with ED50 values of 627.0 mg/kg and 300.0 mg/kg for maximal electroshock and metrazol-induced convulsions, respectively. The compound shows neurotoxicity with TD50 values ranging from 810 mg/kg to 1070 mg/kg depending on the test, including rotarod assays. Its partition coefficient (logP) is -0.37, suggesting low hydrophobicity. The compound also displays antiviral activity against SARS-CoV-2, albeit with lower potency and inhibition rates. Bioactivity assays have indicated hepatotoxic potential, with increases in liver enzyme markers such as ALT, AST, and alkaline phosphatase. Additionally, compound 31804 has been identified as DILI positive in the Drug Induced Liver Injury Prediction System (DILIps). It has shown a protective index (PI) of around 1.07 to 4.3 in seizure models, indicating moderate safety margins. Other bioassays have identified it as a modulator of various enzyme activities and potential inhibitor of HDAC6 and Ebola virus entry, although with varying efficacy..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Trimethadione (3,5,5-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity. |
| Synonyms | 3,5,5,-Trimethyloxazolidine-2,4-dione |
| Molecular Weight | 143.14 |
| Formula | C6H9NO3 |
| Cas No. | 127-48-0 |
| Smiles | CN1C(=O)OC(C)(C)C1=O |
| Relative Density. | 1.171g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (384.24 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.97 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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