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Anti-Phospho-p53 (Ser37) Polyclonal Antibody
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Catalog No. TMAC-02998
Anti-Phospho-p53 (Ser37) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser37). Anti-Phospho-p53 (Ser37) Polyclonal Antibody can be used in WB,IHC,IF,ELISA.
Anti-Phospho-p53 (Ser37) Polyclonal Antibody
Anti-Phospho-p53 (Ser37) Polyclonal Antibody
😃Good
Catalog No. TMAC-02998
Anti-Phospho-p53 (Ser37) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser37). Anti-Phospho-p53 (Ser37) Polyclonal Antibody can be used in WB,IHC,IF,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $218 | 7-10 days | |
| 100 μL | $317 | 7-10 days |
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Chemical Properties
| Description | Anti-Phospho-p53 (Ser37) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser37). Anti-Phospho-p53 (Ser37) Polyclonal Antibody can be used in WB,IHC,IF,ELISA. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of serine 37 (L-P-S(p)-Q-A) derived from Human p53 |
| Antigen Species | human |
| Uniprot ID |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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