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Cefadroxil

Name: Cefadroxil
Brand: TargetMol
SKU: T0366
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0366Cas No. 50370-12-2

Alias BL-S 578

Cefadroxil (BL-S 578) is a Cephalosporin Antibacterial. The chemical classification of cefadroxil anhydrous is Cephalosporins.

Cefadroxil

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Purity: 97.54%

Catalog No. T0366Alias BL-S 578Cas No. 50370-12-2

Cefadroxil (BL-S 578) is a Cephalosporin Antibacterial. The chemical classification of cefadroxil anhydrous is Cephalosporins.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$36	In Stock	In Stock
200 mg	$58	In Stock	-
1 mL x 10 mM (in DMSO)	$41	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:97.54%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Cefadroxil AI Summary

Cefadroxil exhibits diverse pharmacological activities and has been extensively studied for its bioactivity. It shows significant binding affinity against various membrane transport proteins, including PEPT1 and PEPT2, with Ki values of 7,200,000 nM and 3,000 nM, respectively. It also impacts human MRP2-mediated estradiol-17-beta-glucuronide transport, showing 68.0% activity relative to control, and demonstrates moderate inhibitory activity in OAT3 transport with IC50 and Ki values of 1,780,000 nM and 8,620 nM, respectively. Pharmacokinetically, Cefadroxil has a total body clearance of 2.5 mL/min/kg and renal clearance of 2.33 mL/min/kg, indicating efficient clearance from both the body and kidneys. It has a low volume of distribution at steady state (0.23 L/kg) and moderate plasma protein binding (fraction unbound of 0.39). The compound has a half-life of 1.1 hours, a mean residence time of 1.5 hours, and demonstrates high oral bioavailability with a low human intestinal absorption rate of 1.0%. In terms of antiviral activity, Cefadroxil inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells by 31.91% at 10 µM after 48 hours. However, its efficacy against the SARS-CoV-2 3CL-Pro protease was limited, showing only 14.01% inhibition at 20 µM. Additionally, it exhibits moderate hepatotoxicity, elevating serum liver enzymes, and has a Hepatic Side Effect score of 1.0, indicating a potential for hepatic failure. Cefadroxil also demonstrated inhibitory effects on various transporters, with significant inhibition percentages seen in OATP2B1, OATP1B1, and OATP1B3 assays. However, it showed negligible inhibitory effects on the uptake of substrates in some transport assays, indicating transporter specificity. The compound's LogD7.4 value of -0.86 suggests low lipid affinity, and its intrinsic clearance rate in rat hepatocytes is less than 3.0 uL/min/million cells, indicating a low metabolic clearance rate. Overall, Cefadroxil exhibits complex bioactivity with specific affinity toward transporters and receptors, moderate clearance characteristics, potential hepatotoxicity, and some antiviral properties against SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cefadroxil (BL-S 578) is a Cephalosporin Antibacterial. The chemical classification of cefadroxil anhydrous is Cephalosporins.
Synonyms	BL-S 578

Chemical Properties

Molecular Weight	363.39
Formula	C₁₆H₁₇N₃O₅S
Cas No.	50370-12-2
Smiles	[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccc(O)cc1)C(O)=O
Relative Density.	1.59g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 9.17 mg/mL (25.23 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7519 mL	13.7593 mL	27.5186 mL	137.5932 mL
5 mM	0.5504 mL	2.7519 mL	5.5037 mL	27.5186 mL
10 mM	0.2752 mL	1.3759 mL	2.7519 mL	13.7593 mL
20 mM	0.1376 mL	0.6880 mL	1.3759 mL	6.8797 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc