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Mal-PEG4-VA-PBD

Name: Mal-PEG4-VA-PBD
Brand: TargetMol
SKU: T18289
Rating: 4.5 (1 reviews)

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Mal-PEG4-VA-PBD is a commonly used linker-toxin conjugate structure in antibody-drug conjugates (ADCs). It consists of Mal for conjugation to antibody thiols, PEG4 as a hydrophilic spacer arm to improve solubility, VA as a dipeptide linker cleavable by lysosomal proteases, and a pyrrolobenzodiazepine (PBD) DNA alkylator as the cytotoxic payload. Mal-PEG4-VA-PBD is cleaved by proteases upon cell entry to release PBD, which then forms covalent adducts with DNA and induces cell death.

Cas No. 1342820-68-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$905	10-14 weeks	10-14 weeks
5 mg	$1,950	10-14 weeks	10-14 weeks
10 mg	$3,120	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks
100 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	1294.41
Formula	C₆₈H₇₉N₉O₁₇
Cas No.	1342820-68-1
Smiles	O=C1N2[C@@](CC(=C2)C3=CC=C(NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCNC(CCN4C(=O)C=CC4=O)=O)=O)C(C)C)=O)C)=O)C=C3)(C=NC=5C1=CC(OC)=C(OCCCOC6=C(OC)C=C7C(=C6)N=C[C@]8(N(C7=O)C=C(C8)C9=CC=C(OC)C=C9)[H])C5)[H]
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 152 mg/mL (117.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7726 mL	3.8628 mL	7.7255 mL	38.6276 mL
5 mM	0.1545 mL	0.7726 mL	1.5451 mL	7.7255 mL
10 mM	0.0773 mL	0.3863 mL	0.7726 mL	3.8628 mL
20 mM	0.0386 mL	0.1931 mL	0.3863 mL	1.9314 mL
50 mM	0.0155 mL	0.0773 mL	0.1545 mL	0.7726 mL
100 mM	0.0077 mL	0.0386 mL	0.0773 mL	0.3863 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc