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Peretinoin

🥰Excellent
Catalog No. TQ0064Cas No. 81485-25-8
Alias NIK333

Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.

Peretinoin

Peretinoin

🥰Excellent
Purity: 97.23%
Catalog No. TQ0064Alias NIK333Cas No. 81485-25-8
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$34In StockIn Stock
2 mg$47In StockIn Stock
5 mg$80In StockIn Stock
10 mg$128In StockIn Stock
25 mg$243In StockIn Stock
50 mg$423In StockIn Stock
100 mg$629In StockIn Stock
500 mg$1,350-In Stock
1 mL x 10 mM (in DMSO)$89In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.23%
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COA HNMR LCMS HPLC

Product Introduction

Bioactivity
Description
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
In vitro
Peretinoin (10-40 μM; 12-72 hours) exhibits suppressed SPHK1 expression after 24 h treatment, even at 10 μM and more prominent after 72 h peretinoin treatment [1]. Peretinoin (5 μM; 24 hours) up-regulates the expression of LC3B-II and increases autophagy flux in mouse primary hepatocytes [2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with an EC50 of 9 μM [3].
Cell Research
Cell Line: Mouse primary hepatocytes (MPH) and the human HCC HepG2 cell line. Concentration: 5 μM. Incubation Time: 24 hours [2]
SynonymsNIK333
Chemical Properties
Molecular Weight302.45
FormulaC20H30O2
Cas No.81485-25-8
SmilesCC(C)=CCC\C(C)=C\CC\C(C)=C\C=C\C(\C)=C\C(O)=O
Relative Density.0.943 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (148.78 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.61 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3063 mL16.5317 mL33.0633 mL165.3166 mL
5 mM0.6613 mL3.3063 mL6.6127 mL33.0633 mL
10 mM0.3306 mL1.6532 mL3.3063 mL16.5317 mL
20 mM0.1653 mL0.8266 mL1.6532 mL8.2658 mL
50 mM0.0661 mL0.3306 mL0.6613 mL3.3063 mL
100 mM0.0331 mL0.1653 mL0.3306 mL1.6532 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SphKSphingosine kinaseS1PReceptorS1P ReceptorRXRRetinoidReceptorRetinoid X receptorsRetinoid ReceptorRetinoic acid receptorsRAR/RXRRARPeretinoinNIK-333NIK 333InhibitorinhibitHepatitis C virusHCVProteaseHCV ProteaseHCVAutophagy
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