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Peretinoin

Name: Peretinoin
Brand: TargetMol
SKU: TQ0064
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0064Cas No. 81485-25-8

Alias NIK333

Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.

Peretinoin

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Purity: 97.23%

Catalog No. TQ0064Alias NIK333Cas No. 81485-25-8

Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$47	In Stock
5 mg	$80	In Stock
10 mg	$128	In Stock
25 mg	$243	In Stock
50 mg	$423	In Stock
100 mg	$629	In Stock
500 mg	$1,350	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Batch Information

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Purity:97.23%

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
In vitro	Peretinoin (10-40 μM; 12-72 hours) exhibits suppressed SPHK1 expression after 24 h treatment, even at 10 μM and more prominent after 72 h peretinoin treatment [1]. Peretinoin (5 μM; 24 hours) up-regulates the expression of LC3B-II and increases autophagy flux in mouse primary hepatocytes [2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with an EC50 of 9 μM [3].
Cell Research	Cell Line: Mouse primary hepatocytes (MPH) and the human HCC HepG2 cell line. Concentration: 5 μM. Incubation Time: 24 hours [2]
Synonyms	NIK333

Chemical Properties

Molecular Weight	302.45
Formula	C₂₀H₃₀O₂
Cas No.	81485-25-8
Smiles	CC(C)=CCC\C(C)=C\CC\C(C)=C\C=C\C(\C)=C\C(O)=O
Relative Density.	0.943 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (148.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3063 mL	16.5317 mL	33.0633 mL	165.3166 mL
5 mM	0.6613 mL	3.3063 mL	6.6127 mL	33.0633 mL
10 mM	0.3306 mL	1.6532 mL	3.3063 mL	16.5317 mL
20 mM	0.1653 mL	0.8266 mL	1.6532 mL	8.2658 mL
50 mM	0.0661 mL	0.3306 mL	0.6613 mL	3.3063 mL
100 mM	0.0331 mL	0.1653 mL	0.3306 mL	1.6532 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc