Pyrazinamide-KLH is an antigen-adjuvant conjugate made from Pyrazinamide and keyhole limpet hemocyanin (KLH). This conjugation of the antigen with a protein adjuvant can enhance the generation of antigen-specific antibodies in vaccine models. The conjugate does not disrupt protein folding or alter primary epitopes, while also promoting cross-presentation and the production of antigen-specific T cells.