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Entecavir

Name: Entecavir
Brand: TargetMol
SKU: T0085L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0085LCas No. 142217-69-4

Alias SQ34676, BMS200475

Entecavir (SQ34676) is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after therapy, but has not been linked to cases of clinically apparent liver injury.

Entecavir

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Purity: 99.14%

Catalog No. T0085LAlias SQ34676, BMS200475Cas No. 142217-69-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$87	In Stock	In Stock
50 mg	$137	In Stock	In Stock
100 mg	$213	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.14%

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Entecavir (SQ34676) is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after therapy, but has not been linked to cases of clinically apparent liver injury.
Targets&IC50	HBV (HepG2 cells):3.75 nM(ec50)
In vitro	BMS-200475 demonstrates potent antiviral activity with an EC50 of 3.75 nM against HBV by integrating into the protein primer of HBV, thereby inhibiting the priming step of the virus's reverse transcriptase. Its efficacy is notably reduced against other RNA and DNA viruses[1]. Entecavir, compared to other deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir, and aciclovir) or lamivudine, undergoes more efficient phosphorylation to its active metabolites. Additionally, entecavir has an intracellular half-life of 15 hours[2].
In vivo	Administering BMS-200475 orally on a daily basis in doses between 0.02 and 0.5 mg/kg of body weight for a duration of one to three months significantly decreases the viremia level of woodchuck hepatitis virus (WHV) in chronically infected woodchucks[3].
Cell Research	BMS 200475 is prepared in phosphate-buffered saline (PBS) and diluted with appropriate medium containing 2% fetal bovine serum. HepG2 2.2.15 cells are plated at a density of 5×105 cells per well on 12-well Biocoat collagen-coated plates and are maintained in a confluent state for 2 to 3 days before being overlaid with 1 mL of medium spiked with BMS 200475. Quantification of HBV was performed on day 10[1].
Synonyms	SQ34676, BMS200475

Chemical Properties

Molecular Weight	277.28
Formula	C₁₂H₁₅N₅O₃
Cas No.	142217-69-4
Smiles	Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@H](O)[C@@H](CO)C1=C
Relative Density.	1.81g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 63.13 mg/mL (227.68 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO+95% Saline: 1 mg/mL (3.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6065 mL	18.0323 mL	36.0646 mL	180.3231 mL
5 mM	0.7213 mL	3.6065 mL	7.2129 mL	36.0646 mL
10 mM	0.3606 mL	1.8032 mL	3.6065 mL	18.0323 mL
20 mM	0.1803 mL	0.9016 mL	1.8032 mL	9.0162 mL
50 mM	0.0721 mL	0.3606 mL	0.7213 mL	3.6065 mL
100 mM	0.0361 mL	0.1803 mL	0.3606 mL	1.8032 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc