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Maslinic acid
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Catalog No. T3772Cas No. 4373-41-5
Alias Crategolic acid, 2α-Hydroxyoleanolic acid, 2α-Hydroxyoleanoic Acid
Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor.
Maslinic acid
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Purity: 99.98%
Catalog No. T3772Alias Crategolic acid, 2α-Hydroxyoleanolic acid, 2α-Hydroxyoleanoic AcidCas No. 4373-41-5
Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $30 | In Stock | In Stock | |
| 5 mg | $61 | In Stock | In Stock | |
| 10 mg | $98 | In Stock | In Stock | |
| 25 mg | $223 | In Stock | In Stock | |
| 50 mg | $333 | In Stock | In Stock | |
| 100 mg | $519 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $61 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.98%
Color:White
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Product Introduction
Maslinic acid AI Summary
Maslinic acid is a versatile bioactive agent exhibiting inhibitory activity against various enzymes and demonstrating substantial cytotoxicity across multiple cell lines. It inhibits rabbit muscle glycogen phosphorylase A with an IC50 value of 28000.0 nM and rat liver glycogen phosphorylase with an IC50 value of 99000.0 nM, suggesting its potential as a glycogen phosphorylase inhibitor. Additionally, it shows significant cytotoxic effects on human Raji cells, reducing cell viability by up to 100% at certain concentrations, while also inducing apoptosis and cell cycle arrest in HIV1-infected human MT2 cells. Maslinic acid demonstrates potent inhibition of TPA-induced EBV-early antigen activation and varying inhibition rates of HIV1 recombinant protease, as well as antiviral activity against pseudo HCV infected human 293T cells and SARS-CoV-2 in VERO-6 cells.
This compound also exhibits cytotoxicity against various cancer cell lines such as 518A2, 8505C, A2780, and A549, with EC50 values ranging from 13700.0 nM to 28800.0 nM, indicating its potential as an anticancer agent. Moreover, it has shown antimalarial activity against Plasmodium falciparum with IC50 values of 21100.0 nM and 8600.0 nM for D6 and W2 strains respectively. Maslinic acid inhibits Toxoplasma gondii RH tachyzoites and demonstrates antibacterial actions against Bacillus thuringiensis and Escherichia coli. Additionally, it displays anti-inflammatory properties in mouse RAW264.7 and BV2 cells and inhibition of mouse bone marrow monocytes' differentiation into osteoclasts. Lastly, Maslinic acid has antifeedant activity against Spodoptera littoralis larvae and moderate anti-obesity effects in a high-fat diet-induced obesity mouse model..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor. |
| Synonyms | Crategolic acid, 2α-Hydroxyoleanolic acid, 2α-Hydroxyoleanoic Acid |
| Molecular Weight | 472.70 |
| Formula | C30H48O4 |
| Cas No. | 4373-41-5 |
| Smiles | CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O |
| Relative Density. | 1.14g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 257.50 mg/mL (544.74 mM), Sonication is recommended.  Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 3.3 mg/mL (6.98 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
RNASynthesisRNA SynthesisNuclear factor-κBNuclear factor-kappaBNF-κBNFκBNF-kBNFkBMaslinic acidInhibitorinhibitHuman immunodeficiency virusHIVProteaseHIV ProteaseHIVDNASynthesisDNA SynthesisDNA polymerase BBacterial2alpha-Hydroxyoleanolic acid2alpha-Hydroxyoleanoic Acid2a-Hydroxyoleanolic acid2a-Hydroxyoleanoic Acid
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