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Altiratinib

Name: Altiratinib
Brand: TargetMol
SKU: T2054
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2054Cas No. 1345847-93-9

Alias DCC-2701

Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist in vitro.

Altiratinib

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Purity: 99.75%

Catalog No. T2054Alias DCC-2701Cas No. 1345847-93-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$79	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$226	In Stock	In Stock
100 mg	$337	-	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.75%

Color:White

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COA HNMR LCMS

Product Introduction

Altiratinib AI Summary

Altiratinib exhibits potent inhibition of various receptor tyrosine kinases, including VEGFR, TrkC, TrkB, TrkA, TIE-2, and MET, with IC50 values ranging from 0.69 nM to 9.2 nM. Additionally, it has demonstrated significant antiproliferative activity against human KM12, SK-N-SH, and K562 cells with IC50 values of 1.4 nM, 1.2 nM, and 0.69 nM, respectively. The compound also shows inhibitory activity against c-MET and HDAC6 enzymes, as well as exhibiting cytotoxic effects against human HepG2 cells with an IC50 of 200.0 nM. Furthermore, Altiratinib has shown antiviral activity against SARS-CoV-2, including inhibition of SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells and moderate inhibition of SARS-CoV-2 3CL-Pro protease. These bioactivities suggest that Altiratinib may have potential therapeutic applications in targeting pathways related to cancer progression, angiogenesis, cellular proliferation, and viral infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist in vitro.
Targets&IC50	TrkA:0.85 nM, MET (Y1230C):0.37 nM, MET (Y1230C):1.2 nM, TrkC:0.85 nM, MET (D1228N):1.3 nM, Trk3:0.93 nM, VEGFR2:9.2 nM, FLT3:9.3 nM, Trk2:4.6 nM, Tie2:8 nM
Synonyms	DCC-2701

Chemical Properties

Molecular Weight	510.46
Formula	C₂₆H₂₁F₃N₄O₄
Cas No.	1345847-93-9
Smiles	Fc1ccc(NC(=O)C2(CC2)C(=O)Nc2cc(F)c(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)cc1
Relative Density.	1.557 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (470.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9590 mL	9.7951 mL	19.5902 mL	97.9509 mL
5 mM	0.3918 mL	1.9590 mL	3.9180 mL	19.5902 mL
10 mM	0.1959 mL	0.9795 mL	1.9590 mL	9.7951 mL
20 mM	0.0980 mL	0.4898 mL	0.9795 mL	4.8975 mL
50 mM	0.0392 mL	0.1959 mL	0.3918 mL	1.9590 mL
100 mM	0.0196 mL	0.0980 mL	0.1959 mL	0.9795 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Altiratinib

Altiratinib

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