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Altiratinib

Name: Altiratinib
Brand: TargetMol
SKU: T2054
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2054Cas No. 1345847-93-9

Alias DCC-2701

Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist in vitro.

Altiratinib

🥰Excellent

Purity: 99.75%

Catalog No. T2054Alias DCC-2701Cas No. 1345847-93-9

Pack Size	Price	Availability
5 mg	$48	In Stock
10 mg	$79	In Stock
25 mg	$139	In Stock
50 mg	$226	In Stock
100 mg	$337	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Purity:99.75%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist in vitro.
Targets&IC50	Trk3:0.93 nM, TrkA:0.85 nM, MET (D1228N):1.3 nM, Tie2:8 nM, VEGFR2:9.2 nM, MET (Y1230C):0.37 nM, FLT3:9.3 nM, MET (Y1230C):1.2 nM, TrkC:0.85 nM, Trk2:4.6 nM
Synonyms	DCC-2701

Chemical Properties

Molecular Weight	510.46
Formula	C₂₆H₂₁F₃N₄O₄
Cas No.	1345847-93-9
Smiles	Fc1ccc(NC(=O)C2(CC2)C(=O)Nc2cc(F)c(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)cc1
Relative Density.	1.557 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (88.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9590 mL	9.7951 mL	19.5902 mL	97.9509 mL
5 mM	0.3918 mL	1.9590 mL	3.9180 mL	19.5902 mL
10 mM	0.1959 mL	0.9795 mL	1.9590 mL	9.7951 mL
20 mM	0.0980 mL	0.4898 mL	0.9795 mL	4.8975 mL
50 mM	0.0392 mL	0.1959 mL	0.3918 mL	1.9590 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc