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Scopolamine

Name: Scopolamine
Brand: TargetMol
SKU: T3S0478
Rating: 4.5 (1 reviews)

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Catalog No. T3S0478Cas No. 51-34-3

Alias Skopolamin, Scopine tropate, Scopine (-)-tropate, Hyoscine

Scopolamine is a high-affinity (nanomolar level) muscarinic receptor antagonist that can reversibly inhibit 5-HT₃ receptor responses (IC₅₀ = 2.09 μM). It is commonly used to induce animal models of Alzheimer's disease or memory impairment.

Scopolamine

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Purity: 99.95%

Catalog No. T3S0478Alias Skopolamin, Scopine tropate, Scopine (-)-tropate, HyoscineCas No. 51-34-3

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Batch Information

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Purity:99.95%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Scopolamine is a high-affinity (nanomolar level) muscarinic receptor antagonist that can reversibly inhibit 5-HT₃ receptor responses (IC₅₀ = 2.09 μM). It is commonly used to induce animal models of Alzheimer's disease or memory impairment.
Targets&IC50	5-HT3:2.09 μM.
Synonyms	Skopolamin, Scopine tropate, Scopine (-)-tropate, Hyoscine

Chemical Properties

Molecular Weight	303.35
Formula	C₁₇H₂₁NO₄
Cas No.	51-34-3
Smiles	CN1[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)c1ccccc1
Relative Density.	1.31

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (247.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2965 mL	16.4826 mL	32.9652 mL	164.8261 mL
5 mM	0.6593 mL	3.2965 mL	6.5930 mL	32.9652 mL
10 mM	0.3297 mL	1.6483 mL	3.2965 mL	16.4826 mL
20 mM	0.1648 mL	0.8241 mL	1.6483 mL	8.2413 mL
50 mM	0.0659 mL	0.3297 mL	0.6593 mL	3.2965 mL
100 mM	0.0330 mL	0.1648 mL	0.3297 mL	1.6483 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc