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(Rac)-Antineoplaston A10

Name: (Rac)-Antineoplaston A10
Brand: TargetMol
SKU: T5379
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5379Cas No. 77658-84-5

Alias Antineoplaston A10

(Rac)-Antineoplaston A10 (Antineoplaston A10) is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferative action inhibiting cell growth.

(Rac)-Antineoplaston A10

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Purity: 98.41%

Catalog No. T5379Alias Antineoplaston A10Cas No. 77658-84-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$131	In Stock	In Stock
25 mg	$220	In Stock	In Stock
50 mg	$328	In Stock	In Stock
100 mg	$472	In Stock	In Stock
200 mg	$659	-	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.41%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	(Rac)-Antineoplaston A10 (Antineoplaston A10) is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferative action inhibiting cell growth.
In vitro	Antineoplaston A10 (2, 4, 8 mg/ml) inhibited cell proliferation time and dose-dependently in all 6 HCC cell lines. A concentration of 8 mg/ml of Antineoplaston A10 was required to inhibit cell proliferation in KIM-1, KYN-3, HAK-1A, and HAK-1B cells [1]. The HepG2 cells, when incubated with 10 μg/ml of antineoplaston A10, had a cell growth inhibition rate of less than 10% for up to 120 h, while cells incubated with 200 μg/ml of antineoplaston A10 had an inhibition rate of 34.9% at 120 h [2].
Synonyms	Antineoplaston A10

Chemical Properties

Molecular Weight	246.26
Formula	C₁₃H₁₄N₂O₃
Cas No.	77658-84-5
Smiles	O=C(Cc1ccccc1)NC1CCC(=O)NC1=O
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (111.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0607 mL	20.3037 mL	40.6075 mL	203.0374 mL
5 mM	0.8121 mL	4.0607 mL	8.1215 mL	40.6075 mL
10 mM	0.4061 mL	2.0304 mL	4.0607 mL	20.3037 mL
20 mM	0.2030 mL	1.0152 mL	2.0304 mL	10.1519 mL
50 mM	0.0812 mL	0.4061 mL	0.8121 mL	4.0607 mL
100 mM	0.0406 mL	0.2030 mL	0.4061 mL	2.0304 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc