(Rac)-Antineoplaston A10 (Antineoplaston A10) is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferative action inhibiting cell growth.

Antineoplaston A10 (2, 4, 8 mg/ml) inhibited cell proliferation time and dose-dependently in all 6 HCC cell lines. A concentration of 8 mg/ml of Antineoplaston A10 was required to inhibit cell proliferation in KIM-1, KYN-3, HAK-1A, and HAK-1B cells [1]. The HepG2 cells, when incubated with 10 μg/ml of antineoplaston A10, had a cell growth inhibition rate of less than 10% for up to 120 h, while cells incubated with 200 μg/ml of antineoplaston A10 had an inhibition rate of 34.9% at 120 h [2].