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Sodium 4-aminosalicylate dihydrate

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Catalog No. T0020Cas No. 6018-19-5
Alias Sodium 4-Aminosalicylate, 4-Amino-salicylic acid sodium salt

Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Sodium 4-aminosalicylate dihydrate exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death.

Sodium 4-aminosalicylate dihydrate
Other Forms of Sodium 4-aminosalicylate dihydrate:

Sodium 4-aminosalicylate dihydrate

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Purity: 99.24%
Catalog No. T0020Alias Sodium 4-Aminosalicylate, 4-Amino-salicylic acid sodium saltCas No. 6018-19-5
Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Sodium 4-aminosalicylate dihydrate exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 g$29-In Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.24%
Appearance:Solid
Color:White
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COA HNMR HPLC LCMS

Product Introduction

Bioactivity
Description
Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Sodium 4-aminosalicylate dihydrate exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death.
In vitro
Following local perfusion with 7.5 mg/mL of 4-aminosalicylate, N-acetyl-5-aminosalicylic acid was detected in the intestines of anesthetized rats.
In vivo
4-Aminosalicylate exhibits effective DPPH radical scavenging activity and rapidly neutralizes hydroperoxyl radicals in aqueous solutions, displaying a concentration-dependent cycle similar to that of Trolox or cysteine, indicative of chain-breaking antioxidant activity. At 0.65 mM, 4-aminosalicylate attenuates the lethal effects of superoxide radicals or hydrogen peroxide on Chinese hamster ovary cells. In cultured mouse peritoneal macrophages, aminosalicylate (25 mM) stimulates phospholipase D in a time- and concentration-dependent manner, and at 5 mM, it enhances protein kinase C activation of PLD. Post-treatment with 4-aminosalicylate (20 mM) results in a 260% increase in inositol 1,4,5-trisphosphate levels in macrophages. Furthermore, in isolated colonic mucosal cells, 4-aminosalicylate (0.1 mM) dose-dependently reduces the synthesis of LTB4, thereby decreasing the LTB4/PGE2 ratio.
SynonymsSodium 4-Aminosalicylate, 4-Amino-salicylic acid sodium salt
Chemical Properties
Molecular Weight211.15
FormulaC7H6NNaO3·2H2O
Cas No.6018-19-5
SmilesO.[Na+].Nc1cc(O)c(cc1)C(=O)[O-].O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 198.9 mM, Sonication is recommended.
DMSO: 55 mg/mL (260.48 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.47 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM4.7360 mL23.6798 mL47.3597 mL236.7985 mL
5 mM0.9472 mL4.7360 mL9.4719 mL47.3597 mL
10 mM0.4736 mL2.3680 mL4.7360 mL23.6798 mL
20 mM0.2368 mL1.1840 mL2.3680 mL11.8399 mL
50 mM0.0947 mL0.4736 mL0.9472 mL4.7360 mL
100 mM0.0474 mL0.2368 mL0.4736 mL2.3680 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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