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Fadrozole hydrochloride

Name: Fadrozole hydrochloride
Brand: TargetMol
SKU: T7556
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: CGS 16949A) Copy Product Info

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Synonyms: CGS 16949A

Catalog No. T7556 Copy Product Info

Purity: 99.55%

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Fadrozole hydrochloride (CGS 16949A) is a model aromatase inhibitor that effectively suppresses estrogen production in fish ovaries.

Cas No. 102676-31-3

Pack Size	Price	USA Stock	Global Stock
5 mg	$40	In Stock	-
10 mg	$64	In Stock	-
25 mg	$128	In Stock	-
50 mg	$213	In Stock	-
100 mg	$372	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$44	In Stock	-

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.55%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Fadrozole hydrochloride (CGS 16949A) is a model aromatase inhibitor that effectively suppresses estrogen production in fish ovaries.
Targets & IC50	Aromatase:1.4 nM (rat), Aromatase:5 nM(human)
In vivo	Fadrozole hydrochloride inhibits growth of androstenedione-stimulated mammary D2 cells implanted into thoracic mammary fat pads of mice by 95% when administered at a dose of 0.5 mg per animal per day.
Synonyms	CGS 16949A

Chemical Properties

Molecular Weight	259.73
Formula	C₁₄H₁₄ClN₃
Cas No.	102676-31-3
Smiles	Cl.N#Cc1ccc(cc1)C1CCCc2cncn12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (385.02 mM), Sonication is recommended.

H2O: 100 mg/mL (385.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.8502 mL	19.2508 mL	38.5015 mL	192.5076 mL
5 mM	0.7700 mL	3.8502 mL	7.7003 mL	38.5015 mL
10 mM	0.3850 mL	1.9251 mL	3.8502 mL	19.2508 mL
20 mM	0.1925 mL	0.9625 mL	1.9251 mL	9.6254 mL
50 mM	0.0770 mL	0.3850 mL	0.7700 mL	3.8502 mL
100 mM	0.0385 mL	0.1925 mL	0.3850 mL	1.9251 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

spontaneous tumourprogesteroneP-450InhibitorinhibitFadrozole hydrochlorideFadrozoleEstrogenAromatase(Rac)-FAD286

Related Tags: Fadrozole hydrochloride chemical structure | Fadrozole hydrochloride in vivo | Fadrozole hydrochloride formula | Fadrozole hydrochloride molecular weight