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Clopamide

Name: Clopamide
Brand: TargetMol
SKU: T6086
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6086Cas No. 636-54-4

Alias Brinaldix, Aquex, Adurix

Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.

Clopamide

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Purity: 99.71%

Catalog No. T6086Alias Brinaldix, Aquex, AdurixCas No. 636-54-4

Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$41	In Stock	-
100 mg	$66	4-6 weeks	4-6 weeks
200 mg	$94	4-6 weeks	4-6 weeks
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Clopamide AI Summary

Clopamide exhibits a range of bioactivities with varying potencies across multiple targets. It shows moderate potency (316.2 nM) in altering Lamin A splicing and a higher potency as an inhibitor of HSD17B4 (19952.6 nM). The compound also exhibits moderate potencies in inducing genomic imprint erasure (5011.9 nM), inhibiting chronic active B-cell receptor signaling (5804.8 nM), and inhibiting cell surface uPA generation (8912.5 nM). It demonstrates good potency (585.8 nM) as a delayed death inhibitor of the malarial parasite plastid after 96 hours of incubation and notable potency (1000.0 nM) in inducing DNA re-replication in SW480 colon adenocarcinoma cells. Additionally, it shows moderate potency (6309.6 nM) as an inhibitor of TDP-43. The compound displays low bioactivity in inhibiting the cell viability of Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.2254, suggesting limited effectiveness compared to the control. It exhibits weak antiviral activity against SARS-CoV-2 in VERO-6 cells with an IC50 value greater than 20000.0 nM. In terms of HDAC6 inhibition, the compound shows a 10.39% inhibition rate using a commercial peptide substrate but -4.01% using a custom peptide substrate. Further assessments indicate that Clopamide demonstrated no significant bioactivity in various assays, showing AC50 values greater than 30000.0 nM across different targets such as ion channels, neurotransmitter receptors, enzymes, and nuclear receptors, and it did not exhibit significant agonist or antagonist effects in the tested in vitro assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.
Synonyms	Brinaldix, Aquex, Adurix

Chemical Properties

Molecular Weight	345.84
Formula	C₁₄H₂₀ClN₃O₃S
Cas No.	636-54-4
Smiles	CC1CCCC(C)N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O
Relative Density.	1.39 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (72.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8915 mL	14.4576 mL	28.9151 mL	144.5755 mL
5 mM	0.5783 mL	2.8915 mL	5.7830 mL	28.9151 mL
10 mM	0.2892 mL	1.4458 mL	2.8915 mL	14.4576 mL
20 mM	0.1446 mL	0.7229 mL	1.4458 mL	7.2288 mL
50 mM	0.0578 mL	0.2892 mL	0.5783 mL	2.8915 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc