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ATV006

Name: ATV006
Brand: TargetMol
SKU: T60014
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60014Cas No. 2647441-36-7

ATV006 has antiviral activity and can be used in research on the treatment of viral infections.

ATV006

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Purity: 99.58%

Catalog No. T60014Cas No. 2647441-36-7

ATV006 has antiviral activity and can be used in research on the treatment of viral infections.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$59	In Stock	In Stock
5 mg	$148	In Stock	In Stock
10 mg	$238	In Stock	In Stock
25 mg	$398	In Stock	In Stock
50 mg	$567	In Stock	In Stock
100 mg	$768	-	In Stock
200 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$159	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.58%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

ATV006 AI Summary

ATV006 exhibits antiviral activity against SARS-CoV-2 with a high inhibitory effect of 99.0% at a 5 μM concentration and boasts an EC50 value of 230.0 nM. The compound demonstrates good stability in simulated intestinal fluid, with 2.0% remaining after 4 hours. In CD-1 mice, it has a half-life of 2.46 hours, a Tmax of 0.42 hours, a Cmax of 18477.42 nM, an AUC of 13817.0 ng·hr·mL⁻¹, and an oral bioavailability of 86.6%. When administered intravenously, it shows a longer half-life of 4.77 hours, an AUC of 7981.0 ng·hr·mL⁻¹, and a volume of distribution at steady state of 4.17 L·kg⁻¹. The compound is well-tolerated with no acute toxicity at a maximum tolerated dose of 1000.0 mg·kg⁻¹, and it has an observed clearance of 86.6 mL·min⁻¹·kg⁻¹ in CD-1 mice..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

ATV006 has antiviral activity and can be used in research on the treatment of viral infections.

Chemical Properties

Molecular Weight	361.35
Formula	C₁₆H₁₉N₅O₅
Cas No.	2647441-36-7
Smiles	CC(C)C(=O)OC[C@H]1O[C@](C#N)([C@H](O)[C@@H]1O)c1ccc2c(N)ncnn12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (152.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7674 mL	13.8370 mL	27.6740 mL	138.3700 mL
5 mM	0.5535 mL	2.7674 mL	5.5348 mL	27.6740 mL
10 mM	0.2767 mL	1.3837 mL	2.7674 mL	13.8370 mL
20 mM	0.1384 mL	0.6919 mL	1.3837 mL	6.9185 mL
50 mM	0.0553 mL	0.2767 mL	0.5535 mL	2.7674 mL
100 mM	0.0277 mL	0.1384 mL	0.2767 mL	1.3837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc