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Anti-LIGHT/TNFSF14 Polyclonal Antibody
😃Good
Catalog No. TMAB-01068
Anti-LIGHT/TNFSF14 Polyclonal Antibody is a Rabbit antibody targeting LIGHT/TNFSF14. Anti-LIGHT/TNFSF14 Polyclonal Antibody can be used in WB,ELISA.
Anti-LIGHT/TNFSF14 Polyclonal Antibody
Anti-LIGHT/TNFSF14 Polyclonal Antibody
😃Good
Catalog No. TMAB-01068
Anti-LIGHT/TNFSF14 Polyclonal Antibody is a Rabbit antibody targeting LIGHT/TNFSF14. Anti-LIGHT/TNFSF14 Polyclonal Antibody can be used in WB,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $528 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-LIGHT/TNFSF14 Polyclonal Antibody is a Rabbit antibody targeting LIGHT/TNFSF14. Anti-LIGHT/TNFSF14 Polyclonal Antibody can be used in WB,ELISA. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat) |
| Verified Activity | Sample: Spleen (Mouse) Lysate at 40 μg Small intestine (Mouse) Lysate at 40 μg Primary: Anti-TNFSF14 (TMAB-01068) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 26 kDa Observed band size: 26 kDa |
| Application | WB,ELISA |
| Recommended Dose | WB: 1:500-2000; ELISA: 1:500-5000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.Isoform 2: Cytoplasm. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as "death domain." LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. This protein was also demonstrated to inhibit TNF-Alpha-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes. |
| Immunogen | KLH conjugated synthetic peptide: human TNFSF14 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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