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Curvulin

Name: Curvulin
Brand: TargetMol
SKU: T36850
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36850Cas No. 19054-27-4

Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly.

Curvulin

🥰Excellent

Purity: 98.65%

Catalog No. T36850Cas No. 19054-27-4

Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly.

Pack Size	Price	Availability
1 mg	$148	In Stock
5 mg	$336	In Stock
10 mg	$497	In Stock
25 mg	$793	In Stock
50 mg	$1,130	In Stock
100 mg	$1,520	In Stock
1 mL x 10 mM (in DMSO)	$298	In Stock

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Batch Information

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Purity:98.65%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly.

Chemical Properties

Molecular Weight	238.24
Formula	C₁₂H₁₄O₅
Cas No.	19054-27-4
Smiles	CCOC(=O)Cc1cc(O)cc(O)c1C(C)=O
Relative Density.	1.273 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (104.94 mM), Sonication is recommended.

Methanol: Soluble

Acetone: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1974 mL	20.9872 mL	41.9745 mL	209.8724 mL
5 mM	0.8395 mL	4.1974 mL	8.3949 mL	41.9745 mL
10 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9872 mL
20 mM	0.2099 mL	1.0494 mL	2.0987 mL	10.4936 mL
50 mM	0.0839 mL	0.4197 mL	0.8395 mL	4.1974 mL
100 mM	0.0420 mL	0.2099 mL	0.4197 mL	2.0987 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc