Shopping Cart
- Remove All
Your shopping cart is currently empty
Trimethylamine N-oxide dihydrate
🥰Excellent
Catalog No. T5247Cas No. 62637-93-8
Alias TMANO Dihydrate
Trimethylamine N-oxide dihydrate (TMANO dihydrate) is a gut microbiota-dependent metabolite derived from dietary choline and other trimethylamine-containing nutrients. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation and cardiac fibrosis via the TGF-β/Smad2 signaling pathway. TMANO dihydrate can be used to establish models of cardiac hypertrophy and cardiac fibrosis.
Trimethylamine N-oxide dihydrate
🥰Excellent
Purity: 98.75%
Catalog No. T5247Alias TMANO DihydrateCas No. 62637-93-8
Trimethylamine N-oxide dihydrate (TMANO dihydrate) is a gut microbiota-dependent metabolite derived from dietary choline and other trimethylamine-containing nutrients. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation and cardiac fibrosis via the TGF-β/Smad2 signaling pathway. TMANO dihydrate can be used to establish models of cardiac hypertrophy and cardiac fibrosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 g | $35 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View MoreBatch Information
Select Batch
Purity:98.75%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | Trimethylamine N-oxide dihydrate (TMANO dihydrate) is a gut microbiota-dependent metabolite derived from dietary choline and other trimethylamine-containing nutrients. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation and cardiac fibrosis via the TGF-β/Smad2 signaling pathway. TMANO dihydrate can be used to establish models of cardiac hypertrophy and cardiac fibrosis. |
| Synonyms | TMANO Dihydrate |
| Molecular Weight | 111.14 |
| Formula | C3H13NO3 |
| Cas No. | 62637-93-8 |
| Smiles | O.O.C[N+](C)(C)[O-] |
| Relative Density. | 1.157 g/cm3 |
Storage & Solubility Information
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (179.95 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (18 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Trimethylamine N-oxide DihydrateTrimethylamine N-oxide dihydrateTrimethylamine Noxide dihydrateTrimethylamine N-oxideTrimethylamine N oxide dihydratetrimethylamineTransforming growth factor betaTMANOTGF-βRITGF-beta/SmadSmad2Reactive Oxygen SpeciesNOD-like Receptor (NLR)myocardialMicrobe-dependentmetaboliteInhibitorinhibitinflammationfibrosisEndogenousMetaboliteEndogenous Metabolitedysfunctioncholinecardiac
Preview
Related Tags: buy Trimethylamine N-oxide dihydrate | purchase Trimethylamine N-oxide dihydrate | Trimethylamine N-oxide dihydrate cost | order Trimethylamine N-oxide dihydrate | Trimethylamine N-oxide dihydrate chemical structure | Trimethylamine N-oxide dihydrate formula | Trimethylamine N-oxide dihydrate molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.