BMPRIB Protein, Human, Recombinant (hFc)

Name: BMPRIB Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-03362
Rating: 4.5 (1 reviews)

(Synonyms: CDw293, bone morphogenetic protein receptor, type IB, ALK-6, ALK6) Copy Product Info

Synonyms: CDw293, bone morphogenetic protein receptor, type IB, ALK-6, ALK6

Catalog No. TMPY-03362 Copy Product Info

BMPRIB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.7 kDa and the accession number is O00238-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$59	7-10 days	7-10 days
10 µg	$95	7-10 days	7-10 days
20 µg	$155	7-10 days	7-10 days
50 µg	$296	7-10 days	7-10 days
100 µg	$497	7-10 days	7-10 days
200 µg	$987	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its ability to inhibit rhBMP4-induced alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.2-1.6 μg/mL in the presence of 25 ng/mL of recombinant human BMP4.
Description	BMPRIB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.7 kDa and the accession number is O00238-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	O00238-1
Construction	A DNA sequence encoding the human ALK6 (NP_001194.1)(Lys14-Arg126) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Lys 14
Protein Purity	> 90 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	CDw293, bone morphogenetic protein receptor, type IB, ALK-6, ALK6
Research Background	BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective transducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.

Chemical Properties

Molecular Weight

39.7 kDa (predicted); 110 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.