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Medroxyprogesterone
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Catalog No. T5040Cas No. 520-85-4
Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
Medroxyprogesterone
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Purity: 99.51%
Catalog No. T5040Cas No. 520-85-4
Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $33 | In Stock | In Stock | |
| 100 mg | $50 | In Stock | In Stock | |
| 500 mg | $148 | In Stock | In Stock | |
| 1 g | $197 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $55 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.51%
Appearance:Solid
Color:White
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Product Introduction
Medroxyprogesterone AI Summary
Medroxyprogesterone exhibits a diverse range of bioactivities, including significant effects on human MRP2-mediated transport with an activity level of 111.0%. The compound demonstrates inhibitory potency against various targets, such as Tau fibril formation, malaria parasite plastid function, and several viruses including Ebola, Lassa, Hepatitis C, and Foot and Mouth Disease virus. It notably inhibits CYP450 2C19 enzyme, glucocorticoid, androgen, and progesterone receptor binding, indicating its potential as an enzyme inhibitor and ligand binder.
In terms of hepatotoxicity, Medroxyprogesterone shows moderate to severe liver toxicity with potential manifestations like elevated serum enzyme levels, severe clinical signs, cytolytic and cholestatic liver toxicity, severe hepatitis, hepatomegaly, and granulomatous liver disease, along with a combined hepatotoxic DILIps score of 5.0. Specific liver injury induction severity is classified at 2.0.
The compound further indicates differential effects on cell viability, maintaining growth in HEK293T and U2OS cells but showing no growth in human fibroblast cells. It has varied antifungal and antibacterial activity, with moderate effects against Pseudomonas aeruginosa and Acinetobacter baumannii.
In the context of antiviral activities, Medroxyprogesterone inhibits SARS-CoV-2 in HRCE cells, exhibits 7.702% inhibition of SARS-CoV-2 3CL-Pro protease at 20µM, and shows mild inhibition of virus-induced cytotoxicity in Caco-2 and VERO-6 cells. Additionally, it affects thermal stability of various protein domains and demonstrates an HDAC6 inhibition potential and a volume of distribution at steady state of Vdss = 4.66 L.kg-1, with a high fraction unbound in human plasma (logFu = 0.1)..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator. |
| Molecular Weight | 344.49 |
| Formula | C22H32O3 |
| Cas No. | 520-85-4 |
| Smiles | [H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C |
| Relative Density. | 1.13g/cm3 |
| Storage | keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 71.43 mg/mL (207.35 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 2.5 mg/mL (7.26 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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