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Tomatidine

Name: Tomatidine
Brand: TargetMol
SKU: TMA0507
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TMA0507 Copy Product Info

Purity: 99.98%

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Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans.

Cas No. 77-59-8

Pack Size	Price	USA Stock	Global Stock
5 mg	$42	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$115	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description

Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans.

In vitro

Staphylococcus aureus (S. aureus) is responsible for difficult-to-treat and relapsing infections and constitutes one of the most problematic pathogens due to its multiple resistances to clinically available antibiotics. Additionally, the ability of S. aureus to develop small-colony variants is associated with a reduced susceptibility to aminoglycoside antibiotics and in vivo persistence. METHODS AND RESULTS: We have recently demonstrated that Tomatidine, a steroid alkaloid isolated from tomato plants, possesses anti-virulence activity against normal strains of S. aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. In addition, Tomatidine has shown antibiotic activity against small-colony variants of S. aureus. CONCLUSIONS: We herein report the first study of the structure-activity relationship of Tomatidine against S. aureus.

Chemical Properties

Molecular Weight	415.65
Formula	C₂₇H₄₅NO₂
Cas No.	77-59-8
Smiles	CC1C2C(CC3C4CCC5CC(O)CCC5(C)C4CCC23C)OC11CCC(C)CN1
Relative Density.	1.0048 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

0.1 M HCl: < 1 mg/mL (insoluble)

DMSO: 0.83 mg/mL (2 mM), Sonication is recommended.

Ethanol: 30 mg/mL (72.18 mM), Sonication and heating are recommended.

Methanol: 30 mg/mL (72.18 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO/Ethanol/Methanol

	1mg	5mg	10mg	50mg
1 mM	2.4059 mL	12.0294 mL	24.0587 mL	120.2935 mL

Ethanol/Methanol

	1mg	5mg	10mg	50mg
5 mM	0.4812 mL	2.4059 mL	4.8117 mL	24.0587 mL
10 mM	0.2406 mL	1.2029 mL	2.4059 mL	12.0294 mL
20 mM	0.1203 mL	0.6015 mL	1.2029 mL	6.0147 mL
50 mM	0.0481 mL	0.2406 mL	0.4812 mL	2.4059 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.