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Crizotinib hydrochloride

Name: Crizotinib hydrochloride
Brand: TargetMol
SKU: T8399
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8399Cas No. 1415560-69-8

Alias PF-02341066 hydrochloride

Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively.

Crizotinib hydrochloride

🥰Excellent

Purity: 98.87%

Catalog No. T8399Alias PF-02341066 hydrochlorideCas No. 1415560-69-8

Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively.

Pack Size	Price	Availability
5 mg	$31	In Stock
10 mg	$48	In Stock
25 mg	$75	In Stock
50 mg	$101	In Stock
100 mg	$140	In Stock
200 mg	$174	In Stock
500 mg	$239	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Purity:98.87%

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COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively.
Targets&IC50	ALK:20 nM , c-Met:8 nM
In vitro	Crizotinib hydrochloride(PF-2341066)potently inhibited NPM-ALK phosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean IC(50) value, 24 nmol/L).?In biochemical and cellular screens, PF-2341066 was shown to be selective for c-Met and ALK at pharmacologically relevant concentrations across a panel of >120 diverse kinases.?PF-2341066 potently inhibited cell proliferation, which was associated with G(1)-S-phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC(50) values, approximately 30 nmol/L) but not ALK-negative lymphoma cells[1].
Synonyms	PF-02341066 hydrochloride

Chemical Properties

Molecular Weight	486.8
Formula	C₂₁H₂₃Cl₃FN₅O
Cas No.	1415560-69-8
Smiles	Cl.C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Relative Density.	no data available
Color	Brown
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (20.54 mM), Sonication is recommended.

H2O: 50 mg/mL (102.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0542 mL	10.2712 mL	20.5423 mL	102.7116 mL
5 mM	0.4108 mL	2.0542 mL	4.1085 mL	20.5423 mL
10 mM	0.2054 mL	1.0271 mL	2.0542 mL	10.2712 mL
20 mM	0.1027 mL	0.5136 mL	1.0271 mL	5.1356 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0411 mL	0.2054 mL	0.4108 mL	2.0542 mL
100 mM	0.0205 mL	0.1027 mL	0.2054 mL	1.0271 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc