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Crizotinib hydrochloride

Name: Crizotinib hydrochloride
Brand: TargetMol
SKU: T8399
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8399Cas No. 1415560-69-8

Alias PF-02341066 hydrochloride

Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively.

Crizotinib hydrochloride

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Purity: 98.87%

Catalog No. T8399Alias PF-02341066 hydrochlorideCas No. 1415560-69-8

Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$75	In Stock	In Stock
50 mg	$101	In Stock	In Stock
100 mg	$140	In Stock	In Stock
200 mg	$174	-	In Stock
500 mg	$239	-	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.87%

Appearance:Solid

Color:Yellow to Brown

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively.
Targets&IC50	ALK:20 nM , c-Met:8 nM
In vitro	Crizotinib hydrochloride(PF-2341066)potently inhibited NPM-ALK phosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean IC(50) value, 24 nmol/L).?In biochemical and cellular screens, PF-2341066 was shown to be selective for c-Met and ALK at pharmacologically relevant concentrations across a panel of >120 diverse kinases.?PF-2341066 potently inhibited cell proliferation, which was associated with G(1)-S-phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC(50) values, approximately 30 nmol/L) but not ALK-negative lymphoma cells[1].
Synonyms	PF-02341066 hydrochloride

Chemical Properties

Molecular Weight	486.8
Formula	C₂₁H₂₃Cl₃FN₅O
Cas No.	1415560-69-8
Smiles	Cl.C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (20.54 mM), Sonication is recommended.

H2O: 50 mg/mL (102.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0542 mL	10.2712 mL	20.5423 mL	102.7116 mL
5 mM	0.4108 mL	2.0542 mL	4.1085 mL	20.5423 mL
10 mM	0.2054 mL	1.0271 mL	2.0542 mL	10.2712 mL
20 mM	0.1027 mL	0.5136 mL	1.0271 mL	5.1356 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0411 mL	0.2054 mL	0.4108 mL	2.0542 mL
100 mM	0.0205 mL	0.1027 mL	0.2054 mL	1.0271 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc