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Glaucine
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Catalog No. T5S2059Cas No. 475-81-0
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of human breast cancer cells by MMP-9 inhibitory activity, attenuating IκBα and NF-κB activities.
Glaucine
Copy Product Info🥰Excellent
Purity: 99.56%
Catalog No. T5S2059Cas No. 475-81-0
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of human breast cancer cells by MMP-9 inhibitory activity, attenuating IκBα and NF-κB activities.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $35 | In Stock | In Stock | |
| 5 mg | $56 | In Stock | In Stock | |
| 10 mg | $88 | In Stock | In Stock | |
| 25 mg | $148 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.56%
Color:White
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Product Introduction
Glaucine AI Summary
Glaucine exhibits a range of bioactivities, particularly as an inhibitor of multiple targets and as a serotonin and dopamine receptor modulator. It demonstrates in vitro inhibitory activity against recombinant CD45 protein tyrosine phosphatase with an IC50 of 88000.0 nM and also shows cytotoxicity against BALB/c mouse spleen cells (CC50 > 100,000.0 nM). Additionally, it inhibits ConA-induced T cell proliferation and LPS-induced B cell proliferation in the same cell model at IC50 values greater than 100,000.0 nM.
In dopamine receptor assays, Glaucine shows significant activity, displacing [3H]SCH-23390 from rat D1 and D2 receptors and inhibiting apomorphine-induced yawning and penile erection in rats at a dose of 40 mg/kg. It inhibits D1 and D2 receptors with Ki values of 2900.0 nM and 2800.0 nM, respectively. The compound demonstrates antioxidant activity by scavenging DPPH free radicals and shows both cytotoxic and antiviral activities against multiple human cell lines and viruses such as Echovirus 13 and Poliovirus type 1 Lsc-2ab.
It also acts as an inhibitor of Clostridium perfringens neuraminidase (IC50 of 96900.0 nM) and manifests significant binding affinities for serotonin receptors, showing high affinity for the 5-HT7 receptor (Ki of 43.0 nM), moderate affinity for the 5-HT1A receptor (Ki of 171.0 nM), and lower affinity for the 5-HT2A receptor (Ki of 966.0 nM). Further, it displays selective binding characteristics towards the 5-HT2B (Ki of 119.0 nM) and 5-HT2C receptors (Ki of 328.0 nM).
Moreover, Glaucine enhances the cytotoxic effects of doxorubicin and mitoxantrone in human cancer cells by inhibiting P-gp and MRP1, indicating its potential use in overcoming drug resistance. These diverse activities suggest that Glaucine is a multi-target compound with potential applications in modulating immune responses, receptor signaling pathways, antioxidant defenses, and cancer therapy..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of human breast cancer cells by MMP-9 inhibitory activity, attenuating IκBα and NF-κB activities. |
| Targets&IC50 | PDE4:3.4 µM (Ki) |
| Molecular Weight | 355.43 |
| Formula | C21H25NO4 |
| Cas No. | 475-81-0 |
| Smiles | O(C)C1=C2C=3[C@](CC=4C2=CC(OC)=C(OC)C4)(N(C)CCC3C=C1OC)[H] |
| Relative Density. | 1.166g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (84.4 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.63 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α-adrenoceptorPhosphodiesterase (PDE)phosphodiesterasePDE4O,O-DimethylisoboldineNSC-34396NSC34396NSC 34396InhibitorinhibitInfluenzaVirusInfluenza VirusGlaucineDopamineReceptorDopamine ReceptorDopaminecAMPCalciumChannelCalcium ChannelCa2+ channelsCa2+Ca channelsbronchodilationBeta Receptorantiviralantitussiveantioxidativeanti-inflammatoryanti-arthriticalkaloidAdrenergicReceptorAdrenergic Receptor
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