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Decoglurant

Name: Decoglurant
Brand: TargetMol
SKU: T15090
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15090Cas No. 911115-16-7

Alias RO4995819

Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3, developed as an antidepressant.

Decoglurant

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Purity: 99.77%

Catalog No. T15090Alias RO4995819Cas No. 911115-16-7

Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3, developed as an antidepressant.

Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$119	In Stock
10 mg	$176	In Stock
25 mg	$326	In Stock
50 mg	$457	In Stock
100 mg	$636	In Stock
200 mg	$857	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock

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Batch Information

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Purity:99.77%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3, developed as an antidepressant.
Synonyms	RO4995819

Chemical Properties

Molecular Weight	447.34
Formula	C₂₁H₁₁F₆N₅
Cas No.	911115-16-7
Smiles	Nc1ccc(cn1)C#Cc1cnn2c(cc(nc12)-c1ccc(cc1)C(F)(F)F)C(F)(F)F
Relative Density.	no data available
Color	orange
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 230 mg/mL (514.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2354 mL	11.1772 mL	22.3544 mL	111.7718 mL
5 mM	0.4471 mL	2.2354 mL	4.4709 mL	22.3544 mL
10 mM	0.2235 mL	1.1177 mL	2.2354 mL	11.1772 mL
20 mM	0.1118 mL	0.5589 mL	1.1177 mL	5.5886 mL
50 mM	0.0447 mL	0.2235 mL	0.4471 mL	2.2354 mL
100 mM	0.0224 mL	0.1118 mL	0.2235 mL	1.1177 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc