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CCMI

Name: CCMI
Brand: TargetMol
SKU: T7422
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7422Cas No. 917837-54-8

Alias AVL-3288

CCMI (AVL-3288) is a potent and selective modulator of α7 nAChR-positive allosteric sites.

CCMI

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Catalog No. T7422Alias AVL-3288Cas No. 917837-54-8

CCMI (AVL-3288) is a potent and selective modulator of α7 nAChR-positive allosteric sites.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$137	In Stock	In Stock
50 mg	$196	-	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

CCMI AI Summary

CCMI exhibits significant bioactivity as a positive allosteric modulator of human alpha-7 nicotinic acetylcholine receptors (nAChR) expressed in Xenopus oocytes. It enhances the response to acetylcholine (ACh), choline, and nicotine by modulating the induced currents with various EC50 values. The compound also affects GABAA alpha-2-beta-3-gamma-2L receptors and demonstrates differing EC50 values for GABA-induced current modulation. Notably, CCMI displaces [125I]alpha-bungarotoxin from alpha-7 nAChR in rat brain regions, exhibiting distinct IC50 and Ki values. Additionally, it exhibits activity in SH-SY5Y cells and shows measurable drug uptake in DBA/2 mouse brains following intravenous and oral administration. Specifically, at 0.3 mg/kg intravenously, the uptake is 1.0 µM after 10 minutes and 0.3 µM after 90 minutes; when administered orally to NSA mice, the uptake is 0.15 µM after 120 to 150 minutes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CCMI (AVL-3288) is a potent and selective modulator of α7 nAChR-positive allosteric sites.
Synonyms	AVL-3288

Chemical Properties

Molecular Weight	388.25
Formula	C₁₉H₁₅Cl₂N₃O₂
Cas No.	917837-54-8
Smiles	Cc1cc(on1)C(=C/Nc1ccc(Cl)cc1)\C(=O)Nc1ccc(Cl)cc1
Relative Density.	1.412 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (257.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5757 mL	12.8783 mL	25.7566 mL	128.7830 mL
5 mM	0.5151 mL	2.5757 mL	5.1513 mL	25.7566 mL
10 mM	0.2576 mL	1.2878 mL	2.5757 mL	12.8783 mL
20 mM	0.1288 mL	0.6439 mL	1.2878 mL	6.4392 mL
50 mM	0.0515 mL	0.2576 mL	0.5151 mL	2.5757 mL
100 mM	0.0258 mL	0.1288 mL	0.2576 mL	1.2878 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc