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WWL70

Name: WWL70
Brand: TargetMol
SKU: T17260
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17260Cas No. 947669-91-2

WWL70 is a selective inhibitor of alpha/beta hydrolase domain 6 with an IC50 of 70 nM.

WWL70

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Purity: 98.53%

Catalog No. T17260Cas No. 947669-91-2

WWL70 is a selective inhibitor of alpha/beta hydrolase domain 6 with an IC50 of 70 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	In Stock	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$84	In Stock	In Stock
25 mg	$166	In Stock	In Stock
50 mg	$282	In Stock	In Stock
100 mg	$398	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.53%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

WWL70 AI Summary

WWL70 exhibits multifaceted bioactivity, acting as an inhibitor of FAAH, MAGL, and ABHD6 enzymes in mouse brain membrane, with inhibition activities of 102.0%, 95.0%, and 50.0%, respectively. Additionally, it shows potent inhibition of human recombinant ABHD6 with an IC50 value of 70.0 nM and achieves 90.0% inhibition in mouse brain membrane using FP-biotin as a substrate. In terms of antiviral properties, WWL70 displays potential activity against SARS-CoV-2 by inhibiting its 3CL-Pro protease at 20 µM with a 7.15% inhibition rate. It also reduces SARS-CoV-2-induced cytotoxicity in VERO-6 cells by 0.2% at 10 µM after 48 hours, as determined through high content imaging..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	WWL70 is a selective inhibitor of alpha/beta hydrolase domain 6 with an IC50 of 70 nM.
Targets&IC50	ABHD6:70 nM

Chemical Properties

Molecular Weight	437.49
Formula	C₂₇H₂₃N₃O₃
Cas No.	947669-91-2
Smiles	CN(Cc1cccc(c1)-c1ccncc1)C(=O)Oc1ccc(cc1)-c1ccc(cc1)C(N)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (137.15 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2858 mL	11.4288 mL	22.8577 mL	114.2883 mL
5 mM	0.4572 mL	2.2858 mL	4.5715 mL	22.8577 mL
10 mM	0.2286 mL	1.1429 mL	2.2858 mL	11.4288 mL
20 mM	0.1143 mL	0.5714 mL	1.1429 mL	5.7144 mL
50 mM	0.0457 mL	0.2286 mL	0.4572 mL	2.2858 mL
100 mM	0.0229 mL	0.1143 mL	0.2286 mL	1.1429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc