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L-Asparagine
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Catalog No. T2O2774Cas No. 70-47-3
Alias Asparamide, Asn, Altheine, alpha-aminosuccinamic acid, 2-Aminosuccinamic acid, (-)-Asparagine
L-Asparagine (Asparamide) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase.
L-Asparagine
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Purity: 99.95%
Catalog No. T2O2774Alias Asparamide, Asn, Altheine, alpha-aminosuccinamic acid, 2-Aminosuccinamic acid, (-)-AsparagineCas No. 70-47-3
L-Asparagine (Asparamide) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $40 | In Stock | In Stock | |
| 500 mg | $92 | In Stock | In Stock | |
| 1 g | $133 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.95%
Appearance:Solid
Color:White
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Product Introduction
L-Asparagine AI Summary
L-Asparagine, with a partition coefficient (logP) value of 3.41, indicates a lipophilic nature suggestive of good membrane permeability. It functions as a CYP3A4 inhibitor and Retinoic Acid Metabolism Blocking Agent (RAMBA) with an IC50 value greater than 10000.0 nM, impacting drug metabolism in the liver and skin. In vitro studies show it inhibits the D-serine transporter and ASCT2 mediated uptake in various cell types, with significant inhibition at a concentration of 1 mM. It also demonstrates moderate bioactivity in activating human CA1 and Leishmania donovani chagasi CA, but lower activity towards human CA2 and Trypanosoma cruzi CA. Antiviral activity was observed by its inhibition of SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells, and inhibition of the SARS-CoV-2 3CL-Pro protease by 12.61% at 20µM. Additionally, it exhibits inhibitory activity against human HDAC6 and shows low binding affinity towards various human receptors and enzymes, with AC50 values greater than 30,000.0 nM. Despite these various activities, its efficacy and potency at several targets are relatively low..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-Asparagine (Asparamide) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. |
| Synonyms | Asparamide, Asn, Altheine, alpha-aminosuccinamic acid, 2-Aminosuccinamic acid, (-)-Asparagine |
| Molecular Weight | 132.12 |
| Formula | C4H8N2O3 |
| Cas No. | 70-47-3 |
| Smiles | [C@H](CC(N)=O)(C(O)=O)N |
| Relative Density. | 1.543 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 9.9 mg/mL (74.93 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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