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Eclitasertib

Name: Eclitasertib
Brand: TargetMol
SKU: T9702
Price: 108 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9702Cas No. 2125450-76-0

Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).

Eclitasertib

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Purity: 99.85%

Catalog No. T9702Cas No. 2125450-76-0

Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$108	In Stock	In Stock
2 mg	$153	In Stock	In Stock
5 mg	$239	In Stock	In Stock
10 mg	$378	In Stock	In Stock
25 mg	$687	In Stock	In Stock
50 mg	$953	In Stock	In Stock
100 mg	$1,360	In Stock	-
1 mL x 10 mM (in DMSO)	$263	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA LCMS

Product Introduction

Eclitasertib AI Summary

Eclitasertib has anti-necroptotic activity in human HT-29 cells, effectively inhibiting hTNFalpha/Z-VAD-fmk (TSZ)-induced necroptosis and subsequently increasing cell viability with an EC50 of 15.4 nM. Despite its anti-necroptotic properties, the compound also demonstrates cytotoxic effects on human HT-29 cells, with the CC50 for cytotoxicity being greater than 50000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
Targets&IC50	RIPK1:<1 µΜ

Chemical Properties

Molecular Weight	378.38
Formula	C₁₉H₁₈N₆O₃
Cas No.	2125450-76-0
Smiles	CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (330.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6428 mL	13.2142 mL	26.4285 mL	132.1423 mL
5 mM	0.5286 mL	2.6428 mL	5.2857 mL	26.4285 mL
10 mM	0.2643 mL	1.3214 mL	2.6428 mL	13.2142 mL
20 mM	0.1321 mL	0.6607 mL	1.3214 mL	6.6071 mL
50 mM	0.0529 mL	0.2643 mL	0.5286 mL	2.6428 mL
100 mM	0.0264 mL	0.1321 mL	0.2643 mL	1.3214 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc