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Trigonelline chloride

Name: Trigonelline chloride
Brand: TargetMol
SKU: T2927
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2927Cas No. 6138-41-6

Alias Trigonelline hydrochloride, Nicotinic acid N-methylbetaine Hydrochloride, Gynesine Hydrochloride, Coffearine Hydrochloride

Trigonelline chloride (Coffearine Hydrochloride), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.

Trigonelline chloride

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Purity: 99.93%

Catalog No. T2927Alias Trigonelline hydrochloride, Nicotinic acid N-methylbetaine Hydrochloride, Gynesine Hydrochloride, Coffearine HydrochlorideCas No. 6138-41-6

Trigonelline chloride (Coffearine Hydrochloride), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$37	In Stock	In Stock
100 mg	$50	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Trigonelline chloride AI Summary

Trigonelline chloride is a bioactive molecule with varying inhibitor activities across multiple assays. It inhibits HIV1 reverse transcriptase with an IC50 value greater than 200.0 µg/mL. In a scintillation proximity assay, it inhibits COX2 at 100 µM, with less than 30.0% inhibition observed. Notable inhibitory potencies include 100.0 nM for Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), 5011.9 nM for TGF-b in a cytotox counterscreen assay, and 316.2 nM for Hepatitis C Virus (HCV) in a qHTS assay. Additionally, Trigonelline chloride shows antiplasmodial activity against chloroquine-resistant Plasmodium falciparum (IC50 > 100.0 µg/mL), antileishmanial activity against Leishmania donovani (EC50 > 125.0 µg/mL), and antitrypanosomal activity against Trypanosoma brucei brucei (EC50 > 125.0 µg/mL). It also exhibits cytotoxicity against African green monkey Vero cells with an IC50 value greater than 50.0 µg/mL. The compound shows weak inhibitory activity against both electric eel Acetylcholinesterase (AChE) and horse Butyrylcholinesterase (BChE) at a concentration of 2 mg/mL as determined by Ellman's method..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Trigonelline chloride (Coffearine Hydrochloride), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
Synonyms	Trigonelline hydrochloride, Nicotinic acid N-methylbetaine Hydrochloride, Gynesine Hydrochloride, Coffearine Hydrochloride

Chemical Properties

Molecular Weight	173.60
Formula	C₇H₈ClNO₂
Cas No.	6138-41-6
Smiles	C[n+]1cccc(c1)C(=O)O.[Cl-]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.00 mg/mL (23.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.00 mg/mL (5.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7604 mL	28.8018 mL	57.6037 mL	288.0184 mL
5 mM	1.1521 mL	5.7604 mL	11.5207 mL	57.6037 mL
10 mM	0.5760 mL	2.8802 mL	5.7604 mL	28.8018 mL
20 mM	0.2880 mL	1.4401 mL	2.8802 mL	14.4009 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc