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Erythromycin ethylsuccinate

Name: Erythromycin ethylsuccinate
Brand: TargetMol
SKU: T0474
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0474Cas No. 1264-62-6

Alias EES

Erythromycin ethylsuccinate (EES) is a macrolide antibiotic, produced by Streptomyces erythreus.

Erythromycin ethylsuccinate

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Purity: 98%

Catalog No. T0474Alias EESCas No. 1264-62-6

Erythromycin ethylsuccinate (EES) is a macrolide antibiotic, produced by Streptomyces erythreus.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	In Stock	In Stock
200 mg	$40	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Erythromycin ethylsuccinate (EES) is a macrolide antibiotic, produced by Streptomyces erythreus.
In vitro	It inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Synonyms	EES

Chemical Properties

Molecular Weight	862.05
Formula	C₄₃H₇₅NO₁₆
Cas No.	1264-62-6
Smiles	CCOC(=O)CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C
Relative Density.	1.1417 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 158 mg/mL (183.28 mM), Sonication is recommended.

DMSO: 158 mg/mL (183.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (4.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1600 mL	5.8001 mL	11.6003 mL	58.0013 mL
5 mM	0.2320 mL	1.1600 mL	2.3201 mL	11.6003 mL
10 mM	0.1160 mL	0.5800 mL	1.1600 mL	5.8001 mL
20 mM	0.0580 mL	0.2900 mL	0.5800 mL	2.9001 mL
50 mM	0.0232 mL	0.1160 mL	0.2320 mL	1.1600 mL
100 mM	0.0116 mL	0.0580 mL	0.1160 mL	0.5800 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc