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Maleimide

Name: Maleimide
Brand: TargetMol
SKU: T4820
Rating: 4.5 (1 reviews)

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Catalog No. T4820Cas No. 541-59-3

Alias 2,5-Pyrroledione

Maleimide (2,5-Pyrroledione) (2,5-Pyrroledone) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions.

Maleimide

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Purity: 99.29%

Catalog No. T4820Alias 2,5-PyrroledioneCas No. 541-59-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.29%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Maleimide AI Summary

Maleimide is a multifunctional inhibitor with a broad spectrum of bioactivities in various assays targeting different cellular processes and proteins. It inhibits rabbit GSK3 with an IC50 of 6000.0 nM. Additionally, it exhibits inhibitory effects on lipid storage modulators, Schistosoma Mansoni Peroxiredoxins, AmpC Beta-Lactamase, CCR6 receptor, B-Cell Receptor Signaling, Histone Lysine Methyltransferase G9a, Vitamin D receptor, Rango, HP1-beta Chromodomain Interactions, Mammalian Selenoprotein Thioredoxin Reductase 1, Regulator of G Protein Signaling 4, TGF-β, Cell Surface uPA Generation, Hepatitis C Virus, ATXN expression, HIV-1 protein Vpr, and human tyrosyl-DNA phosphodiesterase 1. It also induces synthetic lethality in tumor cells and affects PTHR and PLK1-PDB. The compound displays various potencies across these assays, suggesting its potential as a versatile multi-target inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Maleimide (2,5-Pyrroledione) (2,5-Pyrroledone) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions.
Synonyms	2,5-Pyrroledione

Chemical Properties

Molecular Weight	97.07
Formula	C₄H₃NO₂
Cas No.	541-59-3
Smiles	O=C1NC(=O)C=C1
Relative Density.	1.2493 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (566.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (20.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	10.3018 mL	51.5092 mL	103.0184 mL	515.0922 mL
5 mM	2.0604 mL	10.3018 mL	20.6037 mL	103.0184 mL
10 mM	1.0302 mL	5.1509 mL	10.3018 mL	51.5092 mL
20 mM	0.5151 mL	2.5755 mL	5.1509 mL	25.7546 mL
50 mM	0.2060 mL	1.0302 mL	2.0604 mL	10.3018 mL
100 mM	0.1030 mL	0.5151 mL	1.0302 mL	5.1509 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc