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Cefpiramide sodium

Name: Cefpiramide sodium
Brand: TargetMol
SKU: T14923
Rating: 4.5 (1 reviews)

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Catalog No. T14923Cas No. 74849-93-7

Alias Wy-44635, SM-1652

Cefpiramide sodium (SM-1652; Wy-44635) is a Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.

Cefpiramide sodium

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Catalog No. T14923Alias Wy-44635, SM-1652Cas No. 74849-93-7

Cefpiramide sodium (SM-1652; Wy-44635) is a Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$58	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Cefpiramide sodium (SM-1652; Wy-44635) is a Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.
In vitro	Cefpiramide was moderately susceptible to hydrolysis by a variety of beta-lactamases from Gram-negative bacilli. Cefpiramide inhibited non-enterococcal streptococci, methicillin-susceptible staphylococci, Neisseria gonorrhoeae, N. meningitidis, and beta-lactamase-negative Haemophilus influenzae [1].
In vivo	Cefpiramide inhibited staphylococci and streptococci and had appreciable activity against Streptococcus faecalis and Listeria moncytogenes [3]. Pharmacokinetic studies in mice showed that cefpiramide attained a peak serum concentration of 12 micrograms/ml and a serum half-life of 40 min, which are higher than attained by cefoperazone with values of 4 micrograms/ml and 18 min. These factors may have caused the combined cefpiramide-gentamicin therapy to result in significantly improved survival rates in mice as well as in higher bactericidal titers than the cefoperazone-gentamicin combination [2].
Synonyms	Wy-44635, SM-1652

Chemical Properties

Molecular Weight	635.63
Formula	C₂₅H₂₄N₈NaO₇S₂
Cas No.	74849-93-7
Smiles	[Na].[H][C@]12SCC(CSc3nnnn3C)=C(N1C(=O)[C@H]2NC(=O)[C@H](NC(=O)c1cnc(C)cc1O)c1ccc(O)cc1)C(O)=O \|c:13\|jcExt:v:0:0
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 39 mg/mL (61.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5732 mL	7.8662 mL	15.7324 mL	78.6621 mL
5 mM	0.3146 mL	1.5732 mL	3.1465 mL	15.7324 mL
10 mM	0.1573 mL	0.7866 mL	1.5732 mL	7.8662 mL
20 mM	0.0787 mL	0.3933 mL	0.7866 mL	3.9331 mL
50 mM	0.0315 mL	0.1573 mL	0.3146 mL	1.5732 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc