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Biotin-PEG4-azide

Name: Biotin-PEG4-azide
Brand: TargetMol
SKU: T17583
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17583Cas No. 1309649-57-7

Biotin-PEG4-azide, a biotin-labeled, PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Biotin-PEG4-azide

🥰Excellent

Purity: 99.09%

Catalog No. T17583Cas No. 1309649-57-7

Biotin-PEG4-azide, a biotin-labeled, PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$43	In Stock	In Stock
25 mg	$66	In Stock	In Stock
50 mg	$97	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.09%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Biotin-PEG4-azide, a biotin-labeled, PEG-based PROTAC linker, is utilized in PROTAC synthesis.
In vitro	PROTACs consist of two distinct ligands linked together: one ligand binds to an E3 ubiquitin ligase and the other to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	488.6
Formula	C₂₀H₃₆N₆O₆S
Cas No.	1309649-57-7
Smiles	C(CCCC(NCCOCCOCCOCCOCCN=[N+]=[N-])=O)[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H]
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (255.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0467 mL	10.2333 mL	20.4666 mL	102.3332 mL
5 mM	0.4093 mL	2.0467 mL	4.0933 mL	20.4666 mL
10 mM	0.2047 mL	1.0233 mL	2.0467 mL	10.2333 mL
20 mM	0.1023 mL	0.5117 mL	1.0233 mL	5.1167 mL
50 mM	0.0409 mL	0.2047 mL	0.4093 mL	2.0467 mL
100 mM	0.0205 mL	0.1023 mL	0.2047 mL	1.0233 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc