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Anti-TET3 Polyclonal Antibody
(Synonyms: Tet oncogene family member 3, Tet methylcytosine dioxygenase 3, TET 3, Probable methylcytosine dioxygenase TET3, Methylcytosine dioxygenase TET3, KIAA0401, hCG_40738) Copy Product Info
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Synonyms: Tet oncogene family member 3, Tet methylcytosine dioxygenase 3, TET 3, Probable methylcytosine dioxygenase TET3, Methylcytosine dioxygenase TET3, KIAA0401, hCG_40738
Catalog No. TMAB-01820 Copy Product Info
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Anti-TET3 Polyclonal Antibody is a Rabbit antibody targeting TET3. Anti-TET3 Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P.
Anti-TET3 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-TET3 Polyclonal Antibody is a Rabbit antibody targeting TET3. Anti-TET3 Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P. |
| Synonyms | Tet oncogene family member 3, Tet methylcytosine dioxygenase 3, TET 3, Probable methylcytosine dioxygenase TET3, Methylcytosine dioxygenase TET3, KIAA0401, hCG_40738 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Sheep) |
| Application | |
| Recommended Dose | FCM=2 μg/Test; ICC/IF=1:100-500; IF=1:200-800; IHC-Fr=1:100-500; IHC-P=1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages. |
| Tissue Specificity | Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010] |
| Immunogen | KLH conjugated synthetic peptide: human TET3 |
| Antigen Species | Human |
| Gene Name | TET3 |
| Gene ID | |
| Protein Name | Methylcytosine dioxygenase TET3 |
| Uniprot ID | |
| Biology Area | Methylated DNA Associated |
| Function | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. |
| Molecular Weight | Theoretical: 179 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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