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N-Acetyl-L-tyrosine

Name: N-Acetyl-L-tyrosine
Brand: TargetMol
SKU: T5292
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5292Cas No. 537-55-3

Alias N-Acetyltyrosine, Ac-Tyr-OH

N-Acetyl-L-tyrosine (Ac-Tyr-OH) is a side chain reaction of tyrosine. It converts to tyrosine and then can be used in neurotransmitter treatment as a precursor of cathecholamine.

N-Acetyl-L-tyrosine

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Purity: 99.4%

Catalog No. T5292Alias N-Acetyltyrosine, Ac-Tyr-OHCas No. 537-55-3

N-Acetyl-L-tyrosine (Ac-Tyr-OH) is a side chain reaction of tyrosine. It converts to tyrosine and then can be used in neurotransmitter treatment as a precursor of cathecholamine.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	-	In Stock
500 mg	$53	-	In Stock
1 g	$77	-	In Stock
5 g	$188	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.4%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

N-Acetyl-L-tyrosine AI Summary

N-Acetyl-L-tyrosine has been explored for various bioactivities and exhibits diverse inhibitory effects. It has shown weak in vitro inhibition of the recombinant stromelysin catalytic domain with an IC50 greater than 500,000 nM, indicating minimal impact on the enzyme at the tested concentration. In antibacterial assays, N-Acetyl-L-tyrosine inhibits the growth of Staphylococcus aureus MN8 at both 0.50% and 0.10% concentrations after 24 hours, with activity percentages of 19.9% and 47.5%, respectively. It also significantly reduces toxin TSST-1 production in S. aureus at the same concentrations by 47.1% and 71.5%. In a primary qHTS assay targeting the malarial parasite plastid, N-Acetyl-L-tyrosine exhibits a potency of 21331.3 nM for delayed death inhibitors, and in a cell-based assay for B-Galactocerebrosidase, its potency is 707.9 nM. The compound inhibits L-tryptophan uptake in Xenopus laevis oocytes, with activity rates reported as both 100.0% and 90.0%. For antiviral properties, N-Acetyl-L-tyrosine displays activity against SARS-CoV-2, showing inhibited cytotoxicity in various cellular models. In Caco-2 cells, it achieves an 8.83% inhibition at 10 µM after 48 hours. It also demonstrates a 10.28% inhibition of SARS-CoV-2 3CL-Pro protease activity at 20 µM. Additionally, in VERO-6 cells, the compound has a weak inhibitory effect with an IC50 greater than 20,000 nM and an inhibition rate of 0.03% at 10 µM concentration after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus. Despite these activities, the compound's hit score of 0.135 suggests limited efficacy against the SARS-CoV-2 virus in the tested conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-Acetyl-L-tyrosine (Ac-Tyr-OH) is a side chain reaction of tyrosine. It converts to tyrosine and then can be used in neurotransmitter treatment as a precursor of cathecholamine.
Synonyms	N-Acetyltyrosine, Ac-Tyr-OH

Chemical Properties

Molecular Weight	223.23
Formula	C₁₁H₁₃NO₄
Cas No.	537-55-3
Smiles	C([C@H](NC(C)=O)C(O)=O)C1=CC=C(O)C=C1
Relative Density.	1.2446 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (268.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4797 mL	22.3984 mL	44.7968 mL	223.9842 mL
5 mM	0.8959 mL	4.4797 mL	8.9594 mL	44.7968 mL
10 mM	0.4480 mL	2.2398 mL	4.4797 mL	22.3984 mL
20 mM	0.2240 mL	1.1199 mL	2.2398 mL	11.1992 mL
50 mM	0.0896 mL	0.4480 mL	0.8959 mL	4.4797 mL
100 mM	0.0448 mL	0.2240 mL	0.4480 mL	2.2398 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc