I-BET151 dihydrochloride

Name: I-BET151 dihydrochloride
Brand: TargetMol
SKU: T22845
Rating: 4.5 (1 reviews)

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Catalog No. T22845Cas No. 1883545-47-8

Alias I-BET 151 hydrochloride

I-BET 151 dihydrochloride is a BET bromodomain inhibitor that prevents BET from recruiting to chromatin.

I-BET151 dihydrochloride

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Catalog No. T22845Alias I-BET 151 hydrochlorideCas No. 1883545-47-8

I-BET 151 dihydrochloride is a BET bromodomain inhibitor that prevents BET from recruiting to chromatin.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$1,150	35 days	35 days
50 mg	$4,680	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	I-BET 151 dihydrochloride is a BET bromodomain inhibitor that prevents BET from recruiting to chromatin.
In vitro	I-BET 151 induces MLL-fusion leukemia cell line apoptosis and G0 / G1 cell cycle arrest in vitro and reduces BCL2 expression in NOMO1 cells.
In vivo	I-BET 151 improves the survival rate of two kinds of MLL fusion leukemia mice and enhances the differentiation of human iPSCs into megakaryocytes.
Synonyms	I-BET 151 hydrochloride

Chemical Properties

Molecular Weight	488.37
Formula	C₂₃H₂₃Cl₂N₅O₃
Cas No.	1883545-47-8
Smiles	C[C@H](C1=CC=CC=N1)N2C(C3=C4)=C(NC2=O)C=NC3=CC(C5=C(C)ON=C5C)=C4OC.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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