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Anti-tPA Antibody (2G74) (Synonyms: t-plasminogen activator, T-PA, TPA, Tissue plasminogen activator)

Catalog No. TMAC-04054 Copy Product Info
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Anti-tPA Antibody (2G74) is a Rabbit antibody targeting tPA. Anti-tPA Antibody (2G74) can be used in IHC,WB.

Anti-tPA Antibody (2G74)

Copy Product Info
🥰Excellent
Catalog No. TMAC-04054
Synonyms t-plasminogen activator, T-PA, TPA, Tissue plasminogen activator

Anti-tPA Antibody (2G74) is a Rabbit antibody targeting tPA. Anti-tPA Antibody (2G74) can be used in IHC,WB.

Anti-tPA Antibody
(2G74)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2967-10 days7-10 days
100 μL$4977-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-tPA Antibody (2G74) is a Rabbit antibody targeting tPA. Anti-tPA Antibody (2G74) can be used in IHC,WB.
Synonymst-plasminogen activator, T-PA, TPA, Tissue plasminogen activator
Ig Type
IgG
Clone
2G74
Reactivity
Human,Mouse,Rat
Verified Activity
1. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-PLAT antibody. Counter stained with hematoxylin.
2. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-PLAT antibody. Counter stained with hematoxylin.
verifiedActivityverifiedActivity
Application
Recommended Dose
WB: 1:500-1000; IHC: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgrounduPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator), which are serine proteases and members of the trypsin family, are essential to the intrinsic coagulation system. tPA is primarily involved in fibrinolysis, whereas uPA principally mediates cell migration and tissue remodeling processes. uPA and tPA are responsible for cleaving plasminogen, a large serum β-globulin that is deposited on the Fibrin strands within a thrombus. uPA and tPA preferentially target plasminogen at the Arg-Val bond to produce plasmin (also designated fibrinolysin), which is a trypsin-like enzyme that acts on Arg-Lys bonds in Fibrin and Fibrinogen and contributes to the systematic activation of the coagulation cascade. uPA and tPA each consist of two chains that are designated A and B. The A chain of uPA can be cleaved, resulting in low and high molecular mass forms. uPA and tPA are regulated by the serpin family members PAI-1 and PAI-2, which are serine proteinase inhibitors that complex with uPA, tPA and other targeted proteinases and then slowly disassociate to produce cleaved species that fold into stable inactive conformations.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 63 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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