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Pyridoxal phosphate

🥰Excellent
Catalog No. T3578Cas No. 54-47-7
Alias Vitamin B6 phosphate, Pyridoxyl phosphate, pyridoxal 5'-phosphate, Pyridoxal 5′-phosphate, PLP, PAL-P

Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.

Pyridoxal phosphate
Other Forms of Pyridoxal phosphate:

Pyridoxal phosphate

🥰Excellent
Purity: 99.65%
Catalog No. T3578Alias Vitamin B6 phosphate, Pyridoxyl phosphate, pyridoxal 5'-phosphate, Pyridoxal 5′-phosphate, PLP, PAL-PCas No. 54-47-7
Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 mg$30In StockIn Stock
1 g$33-In Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.65%
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Product Introduction

Bioactivity
Description
Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.
In vitro
Pyridoxal phosphate results in an immediate reduction in the rate of DNA synthesis. Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost.
SynonymsVitamin B6 phosphate, Pyridoxyl phosphate, pyridoxal 5'-phosphate, Pyridoxal 5′-phosphate, PLP, PAL-P
Chemical Properties
Molecular Weight247.14
FormulaC8H10NO6P
Cas No.54-47-7
SmilesC(OP(=O)(O)O)C=1C(C=O)=C(O)C(C)=NC1
Relative Density.1.638 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (1011.57 mM), Sonication is recommended.
H2O: 20.23 mM, Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (10.12 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM4.0463 mL20.2314 mL40.4629 mL202.3145 mL
5 mM0.8093 mL4.0463 mL8.0926 mL40.4629 mL
10 mM0.4046 mL2.0231 mL4.0463 mL20.2314 mL
20 mM0.2023 mL1.0116 mL2.0231 mL10.1157 mL
DMSO
1mg5mg10mg50mg
50 mM0.0809 mL0.4046 mL0.8093 mL4.0463 mL
100 mM0.0405 mL0.2023 mL0.4046 mL2.0231 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

Vitamin B6 PhosphateReverseTranscriptaseReverse TranscriptasePyridoxyl PhosphatePyridoxylPyridoxal phosphatePyridoxal PhosphatePyridoxalInhibitorinhibitEndogenousMetaboliteEndogenous Metabolite
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