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TargetMol | Compound Library

Sodium Channel Targeted Library

Catalog No. L7400

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. According to the trigger that opens the channel for such ions, they can be classified into Voltage-gated sodium channels and ligand-gated sodium channels. Sodium channels are highly selective for the transport of sodium ions across cell membranes. In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Many of the most common neurological disorders, such as epilepsy, migraine, neurodegenerative diseases, and neuropathic pain, involve abnormalities of neuronal excitability. There is a growing body of data that implicates abnormal expression and function of voltage-gated sodium channels (VGSCs) in these disorders. Pharmacological inhibitors of VGSCs have been used for decades to treat epileptic seizures, the most common disease of neuronal excitability, and arrhythmia, and it is becoming increasingly evident that these antiepileptic VGSC blockers might also be efficacious against a broad range of neurological disorders. Sodium channels serve as specific target for a large variety of chemically distinct neurotoxins produced by many different animals and plants. The development of drugs with enhanced selectivity for specific VGSC isoforms might be an effective and novel approach for the treatment of several neurological diseases. TargetMol's Sodium Channel Blocker Library collects 170 reported sodium channel blockers and agonists, and is an ideal tool for screening more selective and efficient drugs targeting potassium channels.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L7400

Sodium Channel Targeted Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 170 sodium channel blockers and agonists for high throughput and high content screening;
  • Targeting different subtypes of sodium channels, such as Nav1.1, Nav1.2, Nav1.3, Nav1.4, etc.
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, some of which are FDA approved;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Sodium Channel
Potassium Channel
Calcium Channel
AChR
Autophagy
Parasite
NMDAR
GABA Receptor
5-HT Receptor
ATPase
Adrenergic Receptor
NF-κB
Apoptosis
Carbonic Anhydrase
Histamine Receptor
iGluR
Norepinephrine
Dopamine Receptor
Antifungal
Mitophagy
Virus Protease
MRP
ERK
Drug Metabolite
P2X Receptor
Monoamine Transporter
GluR
Cytochromes P450
TGF-beta/Smad
EGFR
DNA/RNA Synthesis
Beta-Secretase
Endogenous Metabolite
MEK
Chloride channel
HIV Protease
Na+/Ca2+ Exchanger
HBV
Wnt/beta-catenin
Serotonin Transporter
Serine/threonin kinase
TRP/TRPV Channel
MAO
CSF-1R
PDE
Gamma-secretase
MT Receptor
Reactive Oxygen Species
Stearoyl-CoA Desaturase (SCD)
CaMK
COX
Antibacterial
SARS-CoV
Trk receptor
transporter
IκB/IKK
Beta Amyloid
HDAC
DNA Methyltransferase
Sigma receptor
AhR
Sodium-dependent phosphate transporter