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Anti-DOK5 Polyclonal Antibody
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Catalog No. TMAB-05280
Anti-DOK5 Polyclonal Antibody is a Rabbit antibody targeting DOK5. Anti-DOK5 Polyclonal Antibody can be used in FCM.
Anti-DOK5 Polyclonal Antibody
Anti-DOK5 Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-05280
Anti-DOK5 Polyclonal Antibody is a Rabbit antibody targeting DOK5. Anti-DOK5 Polyclonal Antibody can be used in FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Antigen Details
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| Description | Anti-DOK5 Polyclonal Antibody is a Rabbit antibody targeting DOK5. Anti-DOK5 Polyclonal Antibody can be used in FCM. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Verified Activity | The blue histogram is unstained cells (HepG 2). The Wathet Blue histogram is cells stained with secondary antibody alone. The Orange histogram is cells stained with rabbit IgG isotype control antibody plus secondary antibody. The green histogram is cells stained with Rabbit Anti-DOK5 antibody (TMAB-05280) plus secondary antibody. 5μg in 100μL 1 X PBS containing 0.5% BSA. |
| Application | |
| Recommended Dose | FCM: 5μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4 and Dok-5 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to Insulin and Insulin-like growth factor-1. The gene encoding human Dok-5 maps to chromosomal location 20q13.2. |
| Immunogen | KLH conjugated synthetic peptide: human DOK5/IRS6 |
| Antigen Species | Human |
| Gene Name | DOK5 |
| Gene ID | |
| Protein Name | Docking protein 5 |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
| Molecular Weight | Theoretical: 34 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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