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Ingenol

Name: Ingenol
Brand: TargetMol
SKU: T5S2017
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S2017Cas No. 30220-46-3

Alias (-)-Ingenol

1. Ingenol ((-)-Ingenol) mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to develop new lead compounds to reactivate latent HIV. 3. Ingenol is a weak PKC activator and possesses important anticancer activity.

Ingenol

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Purity: 99.87%

Catalog No. T5S2017Alias (-)-IngenolCas No. 30220-46-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$96	In Stock	In Stock
10 mg	$129	In Stock	In Stock
25 mg	$259	In Stock	In Stock
50 mg	$492	In Stock	In Stock
100 mg	$673	In Stock	In Stock
500 mg	$1,430	-	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Color:White

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Product Introduction

Ingenol AI Summary

Ingenol exhibits a range of biological activities, including enzyme inhibition, cytotoxicity, anti-inflammatory, and antiviral properties. It shows inhibitory activity against electric eel acetylcholinesterase (AChE) and horse butyrylcholinesterase (BChE) enzymes, with inhibition percentages of -4.51% and -1.75%, respectively, at a concentration of 2 mg/ml by Ellman's method. The compound induces necrosis in human HeLa cells with an LC50 greater than 400,000 nM. It also triggers cytokine release (IL-8 and TNFalpha) in human primary epidermal keratinocytes and oxidative burst in polymorphonuclear leukocytes, both with an EC50 of 10,000 nM. In terms of its antiviral activity, Ingenol demonstrates high selectivity against chikungunya virus and HIV2 ROD, showing strong antiviral activity against chikungunya virus and moderate activity against HIV1 and HIV2 strains. Specifically, against HIV1 NL4-3, it has an EC50 value greater than 11,490 nM, and cytotoxicity against human MT4 cells with a CC50 value greater than 11,500 nM, yielding a selectivity index greater than 10.0. Additionally, it inhibits lipopolysaccharide (LPS)-induced nitric oxide production in mouse RAW264.7 cells with an IC50 greater than 20,000 nM, though it exhibits a relatively weak potency with an IC50 greater than 100,000 nM in anti-inflammatory assays. The compound also shows high chemical stability in an aqueous buffer, with a drug recovery of over 95.0% after 16 hours at pH 7.4 based on HPLC analysis. Overall, Ingenol has diverse bioactivities with potential applications in antiviral therapies and biochemical research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Ingenol ((-)-Ingenol) mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to develop new lead compounds to reactivate latent HIV. 3. Ingenol is a weak PKC activator and possesses important anticancer activity.
Targets&IC50	PKC:30 μM(Ki)
Synonyms	(-)-Ingenol

Chemical Properties

Molecular Weight	348.43
Formula	C₂₀H₂₈O₅
Cas No.	30220-46-3
Smiles	C[C@@H]1C[C@@H]2[C@H]([C@@H]3C=C(CO)[C@@H](O)[C@]4(O)[C@@H](O)C(C)=C[C@@]14C3=O)C2(C)C
Relative Density.	1.33g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (143.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8700 mL	14.3501 mL	28.7002 mL	143.5008 mL
5 mM	0.5740 mL	2.8700 mL	5.7400 mL	28.7002 mL
10 mM	0.2870 mL	1.4350 mL	2.8700 mL	14.3501 mL
20 mM	0.1435 mL	0.7175 mL	1.4350 mL	7.1750 mL
50 mM	0.0574 mL	0.2870 mL	0.5740 mL	2.8700 mL
100 mM	0.0287 mL	0.1435 mL	0.2870 mL	1.4350 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc