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Sinomenine

🥰Excellent
Catalog No. T2726Cas No. 115-53-7
Alias Kukoline, Cucoline

Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.

Sinomenine
Other Forms of Sinomenine:
Sinomenine hydrochlorideT29216080-33-7
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Sinomenine

🥰Excellent
Purity: 99.73%
Catalog No. T2726Alias Kukoline, CucolineCas No. 115-53-7
Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 mg$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.73%
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Product Introduction

Bioactivity
Description
Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.
In vivo
Sinomenine is currently believed to primarily mediate its effects through the release of histamine and may also exert anti-rheumatic properties by mechanisms such as inhibiting the synthesis of prostaglandins, leukotrienes, and nitric oxide.
SynonymsKukoline, Cucoline
Chemical Properties
Molecular Weight329.39
FormulaC19H23NO4
Cas No.115-53-7
SmilesCOC1=C[C@@H]2[C@@H]3Cc4ccc(OC)c(O)c4[C@]2(CCN3C)CC1=O
Relative Density.1.3 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 148 mg/mL (449.32 mM), Sonication is recommended.
H2O: 10 mg/mL (30.36 mM), when pH is adjusted to 1 with 1M HCl, sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.14 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.0359 mL15.1796 mL30.3591 mL151.7957 mL
5 mM0.6072 mL3.0359 mL6.0718 mL30.3591 mL
10 mM0.3036 mL1.5180 mL3.0359 mL15.1796 mL
20 mM0.1518 mL0.7590 mL1.5180 mL7.5898 mL
DMSO
1mg5mg10mg50mg
50 mM0.0607 mL0.3036 mL0.6072 mL3.0359 mL
100 mM0.0304 mL0.1518 mL0.3036 mL1.5180 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

SinomenineOpioidReceptorOpioid ReceptorNuclear factor-κBNuclear factor-kappaBNF-κBNFκBNF-kBNFkBInhibitorinhibitAutophagyApoptosis
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