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Sinomenine

Name: Sinomenine
Brand: TargetMol
SKU: T2726
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2726Cas No. 115-53-7

Alias Kukoline, Cucoline

Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.

Sinomenine

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Purity: 99.59%

Catalog No. T2726Alias Kukoline, CucolineCas No. 115-53-7

Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.

Pack Size	Price	Availability	Quantity
100 mg	$29	In Stock

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Purity:99.59%

Resource Download

COA LCMS HNMR LCMS HPLC

Product Introduction

Bioactivity

Description	Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.
In vivo	Sinomenine is currently believed to primarily mediate its effects through the release of histamine and may also exert anti-rheumatic properties by mechanisms such as inhibiting the synthesis of prostaglandins, leukotrienes, and nitric oxide.
Synonyms	Kukoline, Cucoline

Chemical Properties

Molecular Weight	329.39
Formula	C₁₉H₂₃NO₄
Cas No.	115-53-7
Smiles	COC1=C[C@@H]2[C@@H]3Cc4ccc(OC)c(O)c4[C@]2(CCN3C)CC1=O
Relative Density.	1.3 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 148 mg/mL (449.32 mM), Sonication is recommended.

H2O: 10 mg/mL (30.36 mM), when pH is adjusted to 1 with 1M HCl, sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0359 mL	15.1796 mL	30.3591 mL	151.7957 mL
5 mM	0.6072 mL	3.0359 mL	6.0718 mL	30.3591 mL
10 mM	0.3036 mL	1.5180 mL	3.0359 mL	15.1796 mL
20 mM	0.1518 mL	0.7590 mL	1.5180 mL	7.5898 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0607 mL	0.3036 mL	0.6072 mL	3.0359 mL
100 mM	0.0304 mL	0.1518 mL	0.3036 mL	1.5180 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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