Shopping Cart

Your shopping cart is currently empty

Pinosylvin

Name: Pinosylvin
Brand: TargetMol
SKU: T3843
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T3843Cas No. 22139-77-1

Alias 5-Styrylresorcinol, 3,5-stilbenediol

Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.

Pinosylvin

Copy Product Info

😃Good

Purity: 99.91%

Catalog No. T3843Alias 5-Styrylresorcinol, 3,5-stilbenediolCas No. 22139-77-1

Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	In Stock	In Stock
10 mg	$54	In Stock	In Stock
25 mg	$88	In Stock	In Stock
50 mg	$129	In Stock	In Stock
100 mg	$189	In Stock	In Stock
200 mg	$283	-	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Pinosylvin AI Summary

Pinosylvin inhibits the protein-tyrosine kinase p56lck in vitro with an IC50 value of 193,000 nM using angiotensin I and [gamma-32P]-ATP. It also inhibits PGE-2 production in LPS-stimulated RAW264.7 cells with an IC50 value of 10,600 nM, and demonstrates significant anti-inflammatory effects in mouse J774 cells by reducing LPS-induced nitric oxide production, IL6 expression, and MCP1 expression, with IC50 values of 16,600 nM, 32,100 nM, and 38,700 nM, respectively. In addition, it shows ABTS and DPPH radical scavenging activities, displaying a trolox equivalent antioxidant capacity of 2.04 and a DPPH absorbance ratio of 0.52 relative to L-cysteine at 20 μM. The compound also exhibits antimicrobial activity against methicillin-resistant Staphylococcus aureus with MIC values of 125 μg/mL against S. aureus strains 5 and COL. It induces apoptosis in human HL60 cells, with 36.95% cell accumulation at the sub-G1 phase after 48 hours at 200 μM. Furthermore, Pinosylvin inhibits leukotriene formation in activated human neutrophils with an IC50 of 22,700 nM and demonstrates cytotoxicity against mouse Hepa 1c1c7 cells with a cell viability of 61% at 12.5 μM after 24 hours. It possesses various antioxidant activities, inhibiting AAPH-induced peroxidation and Cu2+-induced human LDL peroxidation, and delaying lipid oxidation based on the Rancimat method. The compound shows potent modulation of TRPV1 and TRPA1 receptors, serving as both an inhibitor and agonist with respective IC50 and efficacy values. Additionally, it inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells, with respective inhibition percentages of 114.57% and 133.48% at 10 μM. Pinosylvin is characterized by a log P value of 2.25, indicating moderate lipophilicity which may influence its bioavailability and efficacy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.
Synonyms	5-Styrylresorcinol, 3,5-stilbenediol

Chemical Properties

Molecular Weight	212.24
Formula	C₁₄H₁₂O₂
Cas No.	22139-77-1
Smiles	Oc1cc(O)cc(\C=C\c2ccccc2)c1
Relative Density.	1.252g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 122.5 mg/mL (577.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7116 mL	23.5582 mL	47.1165 mL	235.5824 mL
5 mM	0.9423 mL	4.7116 mL	9.4233 mL	47.1165 mL
10 mM	0.4712 mL	2.3558 mL	4.7116 mL	23.5582 mL
20 mM	0.2356 mL	1.1779 mL	2.3558 mL	11.7791 mL
50 mM	0.0942 mL	0.4712 mL	0.9423 mL	4.7116 mL
100 mM	0.0471 mL	0.2356 mL	0.4712 mL	2.3558 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc