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Carbadox
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Catalog No. T0770Cas No. 6804-07-5
Alias Mecadox, Getroxel
Carbadox (Mecadox) is an antibacterial agent that has been used in veterinary practice for treating swine dysentery and enteritis and for promoting growth. However, its use has been prohibited in the UK following reports of carcinogenicity and mutagenicity.
Carbadox
Copy Product Info🥰Excellent
Purity: 99.73%
Catalog No. T0770Alias Mecadox, GetroxelCas No. 6804-07-5
Carbadox (Mecadox) is an antibacterial agent that has been used in veterinary practice for treating swine dysentery and enteritis and for promoting growth. However, its use has been prohibited in the UK following reports of carcinogenicity and mutagenicity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $30 | In Stock | In Stock | |
| 100 mg | Inquiry | In Stock | In Stock | |
| 500 mg | Inquiry | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.73%
Appearance:Solid
Color:Yellow
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Product Introduction
Carbadox AI Summary
Carbadox exhibits a broad spectrum of bioactivities, including significant antibacterial and antiviral properties. It has demonstrated potent antibacterial effects in both in vitro and in vivo assays against strains such as Escherichia coli, Salmonella choleraesuis, Pasteurella multocida, Streptococcus pyogenes, and Treponema hyodysenteriae, with minimum inhibitory concentrations (MIC) as low as 0.09 to 0.78 µg/mL. In infected mouse models, it shows protective activity at different doses and routes of administration, evidenced by PD50 values ranging from 4.05 to 44.0 mg/kg.
Additionally, Carbadox demonstrates some antiviral activity, particularly against SARS-CoV-2. It inhibits virus-induced cytotoxicity in Vero E6 and Caco-2 cells, although showing variable inhibition rates and IC50 values, including a hit score of 0.1317 in HRCE cell assays and an inhibition rate of -0.03% in Vero-6 cells at a concentration of 10 µM after 48 hours. The compound also exhibits weak inhibition of SARS-CoV-2 3CL-Pro protease and shows minor inhibition of human HDAC6.
Furthermore, Carbadox inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells, and shows a 90.0% drug excretion rate in pigs at a concentration of 50 ppm. It also inhibits human BSEP activity with an IC50 value greater than 939,800 nM, indicating weak potency in this aspect..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Carbadox (Mecadox) is an antibacterial agent that has been used in veterinary practice for treating swine dysentery and enteritis and for promoting growth. However, its use has been prohibited in the UK following reports of carcinogenicity and mutagenicity. |
| Synonyms | Mecadox, Getroxel |
| Molecular Weight | 262.22 |
| Formula | C11H10N4O4 |
| Cas No. | 6804-07-5 |
| Smiles | COC(=O)N\N=C\c1c[n+]([O-])c2ccccc2[n+]1[O-] |
| Relative Density. | 1.447g/cm3 |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.63 mg/mL (10.03 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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