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653-47 hydrochloride

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Catalog No. T8890Cas No. 1224567-46-7

653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.

653-47 hydrochloride
Other Forms of 653-47 hydrochloride:
653-47T88891224678-75-4
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653-47 hydrochloride

🥰Excellent
Purity: 99.14%
Catalog No. T8890Cas No. 1224567-46-7
653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$84In StockIn Stock
5 mg$197In StockIn Stock
10 mg$372In StockIn Stock
25 mg$629In StockIn Stock
50 mg$896In StockIn Stock
100 mg$1,220In StockIn Stock
500 mg$2,450-In Stock
1 mL x 10 mM (in DMSO)$226In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.14%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.
Targets&IC50
CREB:26.3 μM
Chemical Properties
Molecular Weight407.29
FormulaC20H20Cl2N2O3
Cas No.1224567-46-7
SmilesCl.NCCCOc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cc1O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (613.81 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 3.3 mg/mL (8.1 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4553 mL12.2763 mL24.5525 mL122.7627 mL
5 mM0.4911 mL2.4553 mL4.9105 mL24.5525 mL
10 mM0.2455 mL1.2276 mL2.4553 mL12.2763 mL
20 mM0.1228 mL0.6138 mL1.2276 mL6.1381 mL
50 mM0.0491 mL0.2455 mL0.4911 mL2.4553 mL
100 mM0.0246 mL0.1228 mL0.2455 mL1.2276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

transcriptionpotentiateInhibitorinhibitfactorEpigeneticReaderDomainEpigenetic Reader DomainCREBcancers653-47 Hydrochloride65347 hydrochloride653-47653 47 hydrochloride
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