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Anti-DR5 Monoclonal Antibody
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Catalog No. TMAZ-0134
Alias Tumor necrosis factor receptor superfamily member 10B, TNF-related apoptosis-inducing ligand receptor 2, Death receptor 5
Anti-DR5 Monoclonal Antibody is a humanized rabbit antibody targeting DR5. Anti-DR5 Monoclonal Antibody can be used in ELISA,FCM,IF.
Anti-DR5 Monoclonal Antibody
Anti-DR5 Monoclonal Antibody
😃Good
Catalog No. TMAZ-0134Alias Tumor necrosis factor receptor superfamily member 10B, TNF-related apoptosis-inducing ligand receptor 2, Death receptor 5
Anti-DR5 Monoclonal Antibody is a humanized rabbit antibody targeting DR5. Anti-DR5 Monoclonal Antibody can be used in ELISA,FCM,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μg | $220 | 12 days | 12 days | |
| 50 μg | $264 | 12 days | 12 days | |
| 100 μg | $369 | 12 days | 12 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-DR5 Monoclonal Antibody is a humanized rabbit antibody targeting DR5. Anti-DR5 Monoclonal Antibody can be used in ELISA,FCM,IF. |
| Synonyms | Tumor necrosis factor receptor superfamily member 10B, TNF-related apoptosis-inducing ligand receptor 2, Death receptor 5 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of DR5 overexpressed 293F cells with TMAZ-0134BI, followed by goat anti-rabbit IgG-ABflo 647 (red). The isotype control is rabbit IgG (black line). |
| Application | |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of DR5 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in PBS. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed: 10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis |
| Conjucates | Unconjugated |
| Others Formats | Biotin |
| Antibody Types Available | 2 |
| Immunogen | DR5 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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