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NPPB

Name: NPPB
Brand: TargetMol
SKU: T7638
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7638Cas No. 107254-86-4

NPPB is a chloride channel blocker with IC50 of 80 nM .

NPPB

🥰Excellent

Purity: 99.95%

Catalog No. T7638Cas No. 107254-86-4

NPPB is a chloride channel blocker with IC50 of 80 nM .

Pack Size	Price	Availability
10 mg	$50	In Stock
25 mg	$94	In Stock
50 mg	$162	In Stock
100 mg	$279	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Batch Information

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Purity:99.95%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NPPB is a chloride channel blocker with IC50 of 80 nM .
Targets&IC50	Cl- channel:80 nM
In vitro	NPPB has been shown to activate the GPR35-Gαi/o and GPR35-Gα16 pathways in HEK293 cells, inducing intracellular calcium mobilization[1].

Chemical Properties

Molecular Weight	300.31
Formula	C₁₆H₁₆N₂O₄
Cas No.	107254-86-4
Smiles	OC(=O)c1cc(ccc1NCCCc1ccccc1)[N+]([O-])=O
Relative Density.	1.323 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (499.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3299 mL	16.6495 mL	33.2989 mL	166.4946 mL
5 mM	0.6660 mL	3.3299 mL	6.6598 mL	33.2989 mL
10 mM	0.3330 mL	1.6649 mL	3.3299 mL	16.6495 mL
20 mM	0.1665 mL	0.8325 mL	1.6649 mL	8.3247 mL
50 mM	0.0666 mL	0.3330 mL	0.6660 mL	3.3299 mL
100 mM	0.0333 mL	0.1665 mL	0.3330 mL	1.6649 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc