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Anti-ING5 Antibody (8Z922)

😃Good
Catalog No. TMAY-02669
Alias p28ING5, inhibitor of growth family, member 5

Anti-ING5 Antibody (8Z922) is a Mouse antibody targeting ING5. Anti-ING5 Antibody (8Z922) can be used in ELISA.

Anti-ING5 Antibody (8Z922)

Anti-ING5 Antibody (8Z922)

😃Good
Catalog No. TMAY-02669Alias p28ING5, inhibitor of growth family, member 5
Anti-ING5 Antibody (8Z922) is a Mouse antibody targeting ING5. Anti-ING5 Antibody (8Z922) can be used in ELISA.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-ING5 Antibody (8Z922) is a Mouse antibody targeting ING5. Anti-ING5 Antibody (8Z922) can be used in ELISA.
Aliasp28ING5, inhibitor of growth family, member 5
Ig Type
Monoclonal Mouse IgG1
Clone
8Z922
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ING5 (rh ING5; TMPY-02981; Q8WYH8-2; Glu36-Gln84). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundING5 belongs to the ING family. It contains 1 PHD-type zinc finger and is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16, and PHF17. ING5 also is a component of the MOZ/MORF complex which is composed at least of ING5, KAT6A, KAT6B, MEAF6, and one of BRPF1, BRD1/BRPF2, and BRPF3. It interacts with EP300 and TP53. MOZ/MORF complex has a histone H3 acetyltransferase activity. Through chromatin acetylation, ING5 may regulate DNA replication and may function as a transcriptional coactivator. It interacts with H3K4me3 and to a lesser extent with H3K4me2. ING5 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. It can bind TP EP300/p300, a component of the histone acetyltransferase complex, suggesting its involvement in the TP53-dependent regulatory pathway.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human ING5 protein (TMPY-02981)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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